Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

The document reviews the potential of smart hydrogels in diabetic wound healing, highlighting their ability to respond to specific wound characteristics such as acidic pH, high glucose levels, and oxidative stress. These hydrogels offer advantages over traditional dressings by providing controlled drug release, antibacterial and antioxidant effects, and pro-angiogenic and anti-inflammatory properties. They address challenges like persistent inflammation and impaired angiogenesis, adapting to the wound microenvironment to improve therapeutic outcomes. The review emphasizes the promise of stimuli-responsive hydrogels in enhancing diabetic wound management and suggests their potential for clinical adoption, despite challenges in optimizing physiological responses and stability for clinical use.