Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

December 2021 in “ ACS Nano ”

Aziz Maleki, Jiahui He, Shayesteh Bochani, Vahideh Nosrati, Mohammad‐Ali Shahbazi, Baolin Guo

photoresponsive hydrogels photothermal therapy photodynamic therapy photosensitizers photothermal agents transition metal sulfide nanomaterials transition metal oxides nanomaterials metal nanostructure-based photothermal agents carbon-based photothermal agents conjugated polymer-based photothermal agents complex-based photothermal agents photodynamic agents ZnO-based photodynamic agents black-phosphorus-based photodynamic agents TiO2-based photodynamic agents small organic molecule-based photodynamic agents

TLDR Special hydrogels that respond to light can speed up wound healing and prevent infection.

The document discusses the use of multifunctional photoresponsive hydrogels (MPRHs) in wound healing and prevention of infection. These hydrogels combine the benefits of light-based therapies, photothermal therapy (PTT) and photodynamic therapy (PDT), with the biochemical advantages of hydrogels. Various types of MPRHs are prepared using different photosensitizers, photothermal agents (PHTAs) like transition metal sulfide/oxides nanomaterials, metal nanostructure-based PHTAs, carbon-based PHTAs, conjugated polymer or complex-based PHTAs, and photodynamic agents (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, and small organic molecule-based PHDAs. These therapies can alter the microenvironments of bacteria to prevent infection. The document also discusses the challenges and future research directions in the field of MPRHs and their application in wound management.

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