Nanofibrous Dressings Modified with Antibacterial Polylysine and Anti-inflammatory Tannic Acid for Infected Wound Healing

The study investigates the development of nanofibrous dressings modified with antibacterial polylysine (PLys) and anti-inflammatory tannic acid (TA) for enhanced wound healing, particularly in infected wounds common in diabetic patients. These PLys@TA@PLCL nanofibers demonstrated strong antibacterial effects against Staphylococcus aureus, reducing bacterial survival rates to below 10.8%, and promoted anti-inflammatory responses by inducing M2-type macrophage polarization. In vivo experiments on mouse models showed that the dressings effectively inhibited bacterial infection, reduced inflammation, and accelerated wound healing, including in diabetic wounds. The study concludes that these nanofibers enhance wound healing by promoting fibroblast function and collagen deposition, making them a promising option for treating infected wounds.