Tannic Acid-Functionalized 3D Porous Nanofiber Sponge for Antibiotic-Free Wound Healing with Enhanced Hemostasis, Antibacterial, and Antioxidant Properties

The study introduces a tannic acid-functionalized 3D porous nanofiber sponge (3D-TA) for antibiotic-free wound healing, highlighting its enhanced hemostasis, antibacterial, and antioxidant properties. Created through electrospinning, the sponge exhibits high porosity, water absorption, and retention, with significant antibacterial and antioxidant capabilities due to tannic acid. In vivo experiments on 12 male BALB/c mice demonstrated that the 3D-TA sponge significantly accelerates wound healing compared to controls. The sponge's hierarchical porous structure supports cell ingrowth and nutrient exchange, making it a promising alternative to traditional wound dressings, reducing risks associated with antibiotics.