Therapeutic Potential of Extracellular Vesicles Derived from Platycladus Orientalis Leaf in Treating Anxiety, Depression, and Insomnia

    September 2025 in “ Frontiers in Pharmacology ”
    Peiyu Liu, Gang He, Yongping Lu … Min Li
    Studysummary This study suggests that <i>P. orientalis</i> leaf-derived EVs could offer anxiolytic, antidepressant, and sleep-inducing benefits by affecting neurotransmitter levels and reducing inflammation, particularly when administered intranasally.
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    Research cited in this study 7

    1. Extracellular Vesicle-Based Drug Overview: Research Landscape, Quality Control, and Nonclinical Evaluation Strategies Signal Transduction and Targeted Therapy · 2025
    2. Lambertianic Acid from Platycladus Orientalis Inhibits Muscle Atrophy in Dexamethasone-Induced C2C12 Muscle Atrophy Cells Plants · 2025
    3. Platycladus Orientalis Leaf Extract Promotes Hair Growth Via Non-Receptor Tyrosine Kinase ACK1 Activation Current Issues in Molecular Biology · 2024
    4. Antioxidant Properties of Platycladus Orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair Molecules/Molecules online/Molecules annual · 2024
    5. Unlocking the Medicinal Potential of Plant-Derived Extracellular Vesicles: Current Progress and Future Perspectives International journal of nanomedicine · 2024
    6. Simultaneous Determination of Quercitrin, Afzelin, Amentoflavone, Hinokiflavone in Rat Plasma by UFLC-MS-MS and Its Application to the Pharmacokinetics of Platycladus Orientalis Leaves Extract Journal of Chromatographic Science · 2018
    7. Hair Growth Promoting Activity of Cedrol Isolated from the Leaves of Platycladus Orientalis Biomedicine & Pharmacotherapy · 2016