Therapeutic Potential of Extracellular Vesicles Derived from Platycladus Orientalis Leaf in Treating Anxiety, Depression, and Insomnia

The study investigates the therapeutic potential of extracellular vesicles (EVs) derived from Platycladus orientalis leaves in treating anxiety, depression, and insomnia using rodent models. The EVs, administered intranasally, showed significant improvements in anxiety-like behaviors, depression symptoms, and sleep parameters. They normalized neurotransmitter levels (5-HT, GABA), reduced pro-inflammatory cytokines, and increased TGF-β expression, indicating their multimodal therapeutic effects. The study suggests that these plant-derived EVs could offer a novel and promising alternative to conventional treatments for psychiatric disorders, with fewer side effects. However, further research and clinical trials are needed to assess their safety and efficacy in humans.