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    Glossary Epidermal Differentiation

    process where skin cells mature to form protective barrier

    Epidermal differentiation is the process by which cells in the outermost layer of the skin, called the epidermis, mature and change to form a protective barrier. This involves the transformation of basal cells into specialized cells like keratinocytes, which produce keratin, a protein that helps protect the skin from environmental damage. This process is crucial for maintaining skin integrity and function.

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    1. Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages Cells · 2024 · 7 citations
    2. Chapter 3 Expression and Modification of Keratins During Terminal Differentiation of Mammalian Epidermis 1987 · 81 citations
    3. 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles 2021
    4. Colocalization of Cystatin M/E and its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail 2008 · 22 citations
    5. Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain during Epidermal Differentiation 2002 · 25 citations
    6. A function for Rac1 in the terminal differentiation and pigmentation of hair Journal of cell science · 2012 · 11 citations
    7. The role of cathepsin E in terminal differentiation of keratinocytes Biological Chemistry · 2011 · 15 citations
    8. Human Epidermal Transglutaminase Journal of Investigative Dermatology · 1983 · 53 citations
    9. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    10. The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids International review of cell and molecular biology · 2016 · 73 citations
    11. Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23 Journal of cosmetic dermatology · 2023
    12. Transient expression of keratin 19 is induced in originally negative interfollicular epidermal cells by adhesion of suspended cells. PubMed · 2005 · 25 citations
    13. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells Developmental dynamics · 1994 · 253 citations
    14. Epithelial Skin Biology Current Topics in Developmental Biology · 2016 · 118 citations
    15. Involucrin: A Constituent of Cross-Linked Envelopes and Marker of Squamous Maturation 1986 · 23 citations
    16. Dynamics of Hair Follicle Morphogenesis and Skin Homeostasis Deep Blue (University of Michigan) · 2018
    17. Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 2 citations
    18. Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis Frontiers in Bioscience-Landmark · 2022 · 12 citations
    19. Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation 2023
    20. A function for Rac1 in the terminal differentiation and pigmentation of hair Development · 2012
    21. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    22. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005 · 77 citations
    23. Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo Mechanisms of Development · 2003 · 46 citations
    24. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Current Biology · 2001 · 338 citations
    25. N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting Journal of biomedical science · 2015 · 76 citations
    26. FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice 2004 · 58 citations
    27. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations 2011 · 41 citations
    28. The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression Journal of Investigative Dermatology · 2000 · 17 citations
    29. 874 Chromatin architectural protein CTCF controls epidermal barrier formation, hair follicle fate maintenance and suppresses inflammatory responses in the skin epithelium Journal of Investigative Dermatology · 2017
    30. Vitamin D and the Epidermis CRC Press eBooks · 2005