Claudin Expression Modulations Reflect an Injury Response in the Murine Epidermis

The study examined the modulation of Claudin proteins in the mouse epidermis during injury and repair caused by TPA. It found that Claudins, particularly Cldn1, were dynamically regulated, showing changes in expression and localization from membrane to cytoplasm, which normalized by 96 hours. These changes suggested a role in cell proliferation and differentiation, potentially involving protein kinase C, although the mechanisms were not fully understood. The research highlighted the importance of post-translational and gene expression modifications in maintaining epidermal barrier integrity during injury and repair.