The Wound Healing of Fractional Photothermolysis Mimics Scarless Healing with Minimal Myofibroblast Activation

The study reported on the effects of fractional photothermolysis (FP) on wound healing in mice, demonstrating that FP causes epidermal necrosis and dermal collagen denaturation with minimal myofibroblast activation. It was observed that reepithelialization occurred rapidly within 24 hours, while the restoration of the dermal collagen network was slower, taking 4-6 months to regenerate and closely resemble normal collagen in structure. This suggests that FP can be an effective treatment for improving dermal scar formation, as it mimics scarless healing.