The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration
April 2016
in “Journal of Molecular Biology”
TLDR The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.
The document from April 1, 2016, provides a comprehensive review of the factors influencing hair and feather follicle regeneration, focusing on the stem cell niche and its modulation by both micro- and macro-environmental factors. It discusses the role of the immune system, sex hormones, aging, circadian rhythm, and seasonal rhythms in stem cell regulation. The review suggests targeting the stem cell environment rather than the stem cells themselves for therapeutic applications. It also highlights the importance of the skin as a model for studying stem cell biology and the interactions between hair follicles and dermal adipose tissue. The document discusses the effects of prostaglandins, circadian clock genes, and hormones like melatonin and prolactin on hair follicle activity, as well as the impact of androgens on hair characteristics and conditions like androgenetic alopecia. The document does not provide specific study numbers or outcomes, as it is a general review rather than a report on a single study.
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