Secreted Frizzled-Related Protein 2 Induces Follistatin-Like 1 to Regulate Dihydrotestosterone-Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence

    September 2026 in “ Aging Cell ”
    Youming Huang, Qiong Bian, Yeyu Shen … Yibin Fan
    Studysummary This study found that knocking down SFRP2 in an AGA model improved hair regeneration and reduced cellular dysfunction, suggesting that targeting the SFRP2-FSTL1 axis could be a promising therapeutic strategy for androgenetic alopecia.
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    Research cited in this study 29

    1. Bletilla Striata Polysaccharide Promotes Hair Growth and Suppresses Oxidative Stress and Senescence of Dermal Papilla Cells by Inhibiting Prostaglandin-Endoperoxide Synthase 2 International Journal of Biological Macromolecules · 2026
    2. Dahuang-Gancao Decoction Ameliorates Testosterone-Induced Androgenetic Alopecia in Mice Journal of Ethnopharmacology · 2025
    3. Dermal Papilla Cells: From Basic Research to Translational Applications Biology · 2024
    4. Disturbance of Immune Microenvironment in Androgenetic Alopecia Through Spatial Transcriptomics International Journal of Molecular Sciences · 2024
    5. Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants Journal of Cellular and Molecular Medicine · 2024
    6. Ellagic Acid Inhibits Dihydrotestosterone-Induced Ferroptosis and Promotes Hair Regeneration by Activating the Wnt/Beta-Catenin Signaling Pathway Journal of ethnopharmacology · 2024
    7. Necrosulfonamide Promotes Hair Growth and Ameliorates DHT-Induced Hair Growth Inhibition Journal of Dermatological Science · 2024
    8. Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature International journal of molecular sciences · 2024
    9. Medical and Procedural Treatment of Androgenetic Alopecia – Where Are We? Journal of The American Academy of Dermatology · 2023
    10. Medicinal and Edible Plant Allium Macrostemon Bunge for the Treatment of Testosterone-Induced Androgenetic Alopecia in Mice Journal of Ethnopharmacology · 2023
    11. Innovative Approaches and Advances for Hair Follicle Regeneration ACS Biomaterials Science & Engineering · 2023
    12. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    13. Transcriptomic Analysis Identifies Regulators of the Wnt Signalling and Hypoxia-Inducible Factor Pathways as Possible Mediators of Androgenetic Alopecia British Journal of Dermatology · 2022
    14. Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells Molecules · 2022
    15. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
    16. Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways British Journal of Dermatology · 2022
    17. Safflower Oil Body Nanoparticles Deliver hFGF10 to Hair Follicles and Reduce Microinflammation to Accelerate Hair Regeneration in Androgenetic Alopecia International Journal of Pharmaceutics · 2022
    18. Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia Experimental Dermatology · 2022
    19. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    20. Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells Current Issues in Molecular Biology · 2021
    21. Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth Frontiers in Cell and Developmental Biology · 2021
    22. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    23. Androgens Downregulate BMP2, Impairing the Inductive Role of Dermal Papilla Cells on Hair Follicle Stem Cells Differentiation Molecular and Cellular Endocrinology · 2020
    24. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    25. MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2 Journal of cellular physiology · 2019
    26. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    27. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    28. Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation Annals of Dermatology · 2014
    29. Modulation of the Differentiated Phenotype of Keratinocytes of the Hair Follicle and Epidermis Journal of Dermatological Science · 1994