Microneedle-Based Codelivery of Platycladus Orientalis-Derived Extracellular Vesicles and Minoxidil Nanoparticles for Androgenetic Alopecia Treatment

April 2026 in “ ACS Applied Materials & Interfaces ”

Yikun Shang, Ziqiao Li, Y. S. Lin, Qiong’e Sun, Yali Sun, Zhisheng Li, Dandan Zhao, Wanting Liang, Hui Li, Meijing Wang, Xiang Su, Yan He, Xin Chen, Xujie Liu

TLDR A new microneedle treatment combining plant-derived vesicles and minoxidil may improve hair growth for hair loss.

The study investigates a novel treatment for androgenetic alopecia using a microneedle-based system to co-deliver extracellular vesicles derived from Platycladus orientalis and minoxidil nanoparticles. This approach aims to enhance hair growth by combining the regenerative properties of the extracellular vesicles with the well-known hair growth-promoting effects of minoxidil. The chemical components of the extracellular vesicles include various acids, flavonoids, and other compounds that may contribute to their therapeutic effects. The study suggests that this combination therapy could offer a more effective solution for hair loss compared to traditional treatments.

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