Multifunctional Ionic Liquids-Mediated Topical Delivery of Minoxidil and EGCG for Treating Androgenic Alopecia Through Promoting Angiogenesis and Scavenging ROS

May 2024 in “ Chemical engineering journal ”

Qian Luo, Jiao Zhang, Samira Batur, Chuansheng Fu, Wei Chen, Qi Xie, Conglian Yang, Zhiping Zhang

minoxidil epigallocatechin gallate androgenetic alopecia ionic liquids choline geranic acid stratum corneum oxidative stress vascularization hair follicles telogen phase anagen phase MXD EGCG AGA ILs SC

TLDR New treatment using Minoxidil and EGCG with ionic liquids improves hair growth and quality for hair loss.

The study presents a novel treatment for Androgenetic Alopecia (AGA) using a combination of Minoxidil (MXD) and Epigallocatechin gallate (EGCG) delivered through multifunctional ionic liquids (ILs) comprising choline and geranic acid (CGIL). The ILs-based drug delivery system was found to improve the efficiency of delivering MXD and EGCG into the skin, overcoming the skin stratum corneum (SC) barrier. The combined treatment of MXD and EGCG was found to regulate oxidative stress and promote vascularization around hair follicles, thus reshaping the microenvironment for efficient AGA treatment. Compared to commercially available minoxidil, the new treatment facilitated a faster transition of hair follicles from the telogen phase to the anagen phase with a lower dose and frequency of administration. The regenerated hair coverage and quality were also better in the group treated with the new formulation.

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