Plant Nanovesicles Integrate Bioactivity and Transdermal Finasteride Delivery for Androgenetic Alopecia

    November 2025 in “ ACS Applied Materials & Interfaces
    Fan Qi, Huijun Xie, Xun Guo, Liujing He, Gengbin Chen, Ran Ding, Qianqian Dai, Xueli Kuang, Yu Zhang, Yuan Zhang
    TLDR Plant-derived nanovesicles effectively deliver finasteride for hair regrowth in androgenetic alopecia.
    The study explores the use of biomimetic Platycladi cacumen-derived nanovesicles (PcNs) for transdermal delivery of finasteride (FIN) to treat androgenetic alopecia (AGA). These plant-derived nanovesicles enhance skin permeation and local drug retention, reducing oxidative stress and promoting drug accumulation in the skin layers. In a testosterone-induced AGA mouse model, FIN-loaded PcNs effectively reversed hair follicle miniaturization and stimulated hair regeneration, outperforming minoxidil in promoting hair regrowth. The PcNs work by scavenging reactive oxygen species, modulating inflammatory pathways, and upregulating genes related to hair follicle regeneration. This approach offers a promising, safe, and effective strategy for AGA treatment, highlighting the potential of plant-derived nanocarriers in precision dermatology.
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