Nanoparticle Adjuvants Incorporating Haptens Drive Potent Immune Tolerance to Accelerate Hair Regrowth

    January 2025 in “ ACS Applied Materials & Interfaces
    Ni An, Guzailinuer Yasen, Ximu Li, Xianbao Shi, Yongjun Wang, Hongzhuo Liu
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    TLDR Nanoparticles with specific drugs can help regrow hair in alopecia areata.
    This study presents a novel nanoparticle system that co-delivers diphenylcyclopropenone (DPCP) and rapamycin (RAPA) prodrugs to induce immune tolerance and promote hair regeneration in alopecia areata (AA). The nanoparticles were stable, efficiently taken up by antigen-presenting cells, and induced dendritic cells to become tolerogenic in vitro. In a mouse model, these nanoparticles significantly accelerated hair follicle transition from the telogen to anagen phase, enhancing hair regrowth. This approach offers a promising therapeutic strategy for AA and potentially other autoimmune diseases with unclear autoantigens.
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