Nanoparticle Adjuvants Incorporating Haptens Drive Potent Immune Tolerance to Accelerate Hair Regrowth
January 2025
in “
ACS Applied Materials & Interfaces
”
nanoparticle adjuvants haptens diphenylcyclopropenone DPCP rapamycin RAPA immune tolerance hair regeneration alopecia areata AA antigen-presenting cells dendritic cells tolerogenic telogen phase anagen phase hair follicle transition autoimmune diseases nanoparticles hair regrowth alopecia hair loss immune system
Studysummary In this study, a nanoparticle system codelivering diphenylcyclopropenone and rapamycin successfully induced immune tolerance and promoted hair regrowth in a mouse model of alopecia areata, offering a promising new therapeutic strategy for this autoimmune condition.
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