Natural Sweetener Stevioside-Based Dissolving Microneedles Solubilize Minoxidil for the Treatment of Androgenic Alopecia

    October 2025 in “ Advanced Healthcare Materials ”
    Junying Zhang, Tianyu Shao, Hai-Liang Li … Chungyong Wu
    Studysummary This study found that using a stevioside-based microneedle patch significantly increased minoxidil's solubility and skin absorption, promoting hair growth in animal models and achieving 67.5% area coverage by day 35, highlighting the potential of this novel delivery system for androgenetic alopecia treatment.
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    Research cited in this study 19

    1. One-Touch Embeddable Microneedles for Hair Loss Treatment International Journal of Pharmaceutics · 2024
    2. Temperature-Responsive Detachable Microneedles Integrated with Minoxidil Nanoparticle for Effectively Promoting Hair Regrowth Chemical Engineering Journal · 2024
    3. Efficacy and Safety of Combined Microneedling Therapy for Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Journal of Cosmetic Dermatology · 2024
    4. Efficacy and Safety of Combinational Therapy Using Topical Minoxidil and Microneedling for the Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis Archives of Dermatological Research · 2023
    5. Fabrication of Composite Pastes with Minoxidil-Loaded Nanoparticles and Valproic Acid for Androgenetic Alopecia Treatment International Journal of Biological Macromolecules · 2023
    6. Dissolving Microneedles for Alopecia Treatment Colloids and surfaces. B, Biointerfaces · 2023
    7. Dissolving Microneedle Patch Integrated With Microspheres For Long-Acting Hair Regrowth Therapy ACS Applied Materials & Interfaces · 2023
    8. A Comprehensive Review of Microneedling as a Potential Treatment Option for Androgenetic Alopecia Aesthetic Plastic Surgery · 2022
    9. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    10. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    11. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    12. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    13. Microneedles Mediated Bioinspired Lipid Nanocarriers for Targeted Treatment of Alopecia Journal of Controlled Release · 2020
    14. Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment Polymers · 2020
    15. Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia Journal of Controlled Release · 2019
    16. Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth Biomaterials · 2018
    17. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model Annals of Dermatology · 2016
    18. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
    19. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007