One-Touch Embeddable Microneedles for Hair Loss Treatment

December 2024 in “ International Journal of Pharmaceutics ”

Keum‐Yong Seong, Min Jae Kim, Hyeseon Lee, Sodam Kim, Semin Kim, Hoon‐Soo Kim, Eui‐Man Jung, Beum‐Soo An, Seung Yun Yang

embeddable microneedles minoxidil MXD-loaded MNs topical applications in vivo studies MNs Rogaine

Studysummary In animal studies, this research found that minoxidil-loaded air-pocket microneedles improved hair loss treatment efficiency compared to topical application, while effectively sealing punctured skin openings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study presents a new, painless drug delivery system using embeddable microneedles (MNs) for hair loss treatment. These MNs have an air-pocket design that allows them to implant into the skin and release over 90% of the loaded minoxidil within 48 hours, while also sealing skin punctures to reduce infection risk. In vivo studies demonstrated that MXD-loaded MNs were more effective than topical applications, indicating a promising, minimally invasive, and potentially self-administered treatment option for hair loss.

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Research cited in this study

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research Fast-Embeddable Grooved Microneedles by Shear Actuation for Accurate Transdermal Drug Delivery

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This article reviews existing treatments for male-pattern hair loss, noting that while they can slow progression, they generally achieve only partial hair regrowth.

Simultaneous Effects of Tocopheryl Polyethylene Glycol Succinate on Local Hair Growth Promotion and Systemic Absorption of Topically Applied Minoxidil in a Mouse Model

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18 citations , October 2005 in “International Journal of Pharmaceutics”

This study found that incorporating 0.5% TPGS into topical minoxidil solutions enhanced hair growth in mice, although increasing TPGS to 2% decreased effectiveness.

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Minoxidil effectively treats severe hypertension, but watch for side effects.

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397 citations , February 2004 in “British Journal of Dermatology”

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This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.

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236 citations , July 2001 in “Trends in Molecular Medicine”

This review discusses common hair loss conditions and explores how advancements in hair follicle biology might lead to more effective treatments but reports no new results.

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This article discusses the treatment of androgenetic alopecia and alopecia areata with finasteride and minoxidil but reports no new clinical results.

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Minoxidil promotes hair growth in male pattern baldness.