Hair Growth Promoting Effect of Toothpaste in C57BL/6 Mice: Active Components and Their Effects on Genomic Expression

    December 2021 in “ Journal of Applied Biological Chemistry ”
    Seunghyun Ahn, Jung Yeon Lee, Yujeong Shin, Jinkyung Lee, Seol‐Hoon Lee, Sung Yong Park
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    TLDR Toothpaste containing α-tocopherol acetate, l-menthol, and stevioside can promote hair growth in mice.
    The research studied the impact of toothpaste on hair growth in C57BL/6 mice. It was found that applying 10%, 20%, and 50% toothpaste significantly promoted hair growth, with the 20% and 50% groups showing effects earlier than the control group and the group using 3% minoxidil. The study identified a mixture of α-tocopherol acetate, l-menthol, and stevioside as the active components in toothpaste that promote hair growth. However, other components used in toothpaste formulation did not show hair growth effects. Therefore, the hair growth effect of toothpaste is attributed to the mixture of α-tocopherol acetate, l-menthol, and stevioside.
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