February 2025 in “BMC Genomics” This study found that in cashmere goats, melatonin treatments enhanced cashmere growth by stimulating secondary hair follicles, increasing follicle density, and improving yield and quality, highlighting key genes and metabolic pathways involved in this process.
February 2025 in “International Journal of Molecular Sciences” This study found that melatonin may enhance hair follicle stem cell viability by downregulating the nuclear receptor RORA, which otherwise inhibits cell proliferation and promotes apoptosis.
February 2025 in “Biomolecules” This research found that melatonin has a bidirectional effect on hair follicle stem cell survival, improving it at low doses and inhibiting it at high doses.
November 2024 in “Genomics” This study found that exogenous melatonin enhances the development of secondary hair follicles in Cashmere goats by promoting miRNA-mRNA interactions, specifically via the chi-let-7d-5p/WNT2 axis, which suggests a mechanism for melatonin's effects on hair growth involving microRNA regulation.
May 2024 in “Cell proliferation” This study found that melatonin supplementation significantly promoted hair regeneration in a hair depilation mouse model by up-regulating the Wnt/β-catenin signaling pathway in dermal papillae and hair follicle stem cells, suggesting potential implications for human hair loss treatments.
This study found that melatonin promotes the growth of secondary hair follicles in Inner Mongolian cashmere goats by enhancing the activity and proliferation of dermal papilla cells through involving the Wnt10b gene, though the detailed mechanisms remain undetermined.
November 2023 in “Journal of Cosmetic Dermatology” This study concluded that while both 5% topical and 1 mg oral minoxidil significantly improved hair diameter in androgenetic alopecia patients, there was no significant difference in overall effectiveness or patient satisfaction between the treatments.
1 citations
,
September 2023 in “Journal of Investigative Dermatology” This article discusses the mechanisms behind chemotherapy-induced alopecia and the potential for permanent hair loss due to irreversible damage to hair follicle stem cells, but it reports no new clinical findings.
July 2023 in “Frontiers in Veterinary Science” This study found that exogenous melatonin binds to the nuclear receptor RORα in Inner Mongolia cashmere goats, stimulating secondary hair follicle development and promoting villus growth.
April 2023 in “International Journal of Pharmaceutics” In this study, melatonin-loaded Pickering emulsions stabilized by chitosan-dextran sulphate nanoparticles and enhanced with lecithin showed improved photostability, antioxidant activity, and follicular delivery in androgenic alopecia-affected rats, potentially rivaling commercial minoxidil for hair loss treatment.
1 citations
,
April 2023 in “Journal of Animal Science and Biotechnology” This study found that treating cashmere goat kids with melatonin significantly increased secondary hair follicle density, improving cashmere quality and yield, likely through mechanisms involving the MAPK signaling pathway.
15 citations
,
January 2023 in “Journal of Translational Autoimmunity” This review examines recent research on melatonin's biochemical activities, particularly in skin health, but reports no new clinical results and emphasizes its potential for future medical applications.
3 citations
,
September 2022 in “Frontiers in veterinary science” This study identified key genes and signaling pathways involved in cashmere goat hair follicle growth cycles, influenced by melatonin implantation, suggesting a basis for further research on melatonin's regulatory mechanism.
4 citations
,
May 2022 in “PeerJ” This study suggests that melatonin promotes hair growth-related properties in DP cells by activating the AKT/GSK3β/β-catenin signaling pathway through melatonin receptors in a 3D spheroid culture system.
9 citations
,
February 2022 in “BMC Genomics” This study examined gene expression in cashmere goats and identified key pathways and molecular regulators that influence hair follicle growth stages and melatonin's role in promoting cashmere growth.
26 citations
,
February 2022 in “Journal of pineal research” This review examines melatonin's potential effects on human skin and hair follicle pigmentation, highlighting the need to confirm findings from cell cultures in physiological tissue contexts.
5 citations
,
September 2021 in “Dermatologic Therapy” In this triple-blind randomized clinical trial, researchers found that oral minoxidil 0.25 mg tablets were as effective as 2% topical minoxidil for increasing hair diameter and density in women with female pattern hair loss, with similarly minor side effects.
1 citations
,
August 2021 in “Frontiers in Genetics” This study suggests that melatonin may enhance wool growth in cashmere goats by activating sulfur metabolism genes and high-sulfur protein genes, which are crucial for providing sulfur-containing amino acids needed for wool quality.
11 citations
,
June 2021 in “Frontiers in Cell and Developmental Biology” This study found that melatonin may enhance goat cashmere growth by activating Wnt signaling and regulating stem cell pluripotency through mechanisms involving NOGGIN and BMP4 pathways.
8 citations
,
August 2020 in “Domestic Animal Endocrinology” This study found that melatonin treatment improved cashmere production for one cycle in cashmere goats, enhancing fiber quality and follicle activity, but had no effects in the subsequent cycle.
3 citations
,
February 2019 in “Animal biotechnology” In this study, the PLP2 gene was found to promote secondary hair follicle development in Liaoning cashmere goats, with its expression negatively regulated by melatonin and potentially affecting follicle development via the BMP pathway.
12 citations
,
September 2018 in “Naturwissenschaften” This study found that melatonin at 0.2 g/L for 72 hours most effectively enhances cashmere growth in Liaoning cashmere goats by upregulating the lncRNA MTC, which activates NF-kB signaling.
46 citations
,
September 2018 in “Expert Opinion on Drug Delivery” This study reported that nanostructured lipid carriers with melatonin improved hair density and decreased hair loss in patients with androgenic alopecia, suggesting a promising direction for future treatments.
40 citations
,
July 2018 in “European Journal of Pharmaceutical Sciences” This study found that melatonin-loaded vitamin C-based nanovesicles improved hair thickness, density, and reduced hair loss in patients with androgenic alopecia more effectively than melatonin solution.
32 citations
,
May 2018 in “Cell Cycle” This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.
4 citations
,
March 2018 in “Animal biotechnology” This study suggests that the LAMTOR3 gene may play a role in the development of hair follicles and cashmere growth in Liaoning cashmere goats by influencing the MAPK signaling pathway.
142 citations
,
February 2016 in “Science” This review discusses the role of Foxc1 and type XVII collagen in hair follicle stem cell quiescence and aging, identifying mechanisms that relate to hair thinning and hair loss, and reports no new results.
39 citations
,
January 2012 in “International Journal of Trichology” This study found that topical melatonin solution was associated with positive effects on hair density and reduction in hair loss for androgenetic alopecia, with good tolerability reported in several clinical trials.
109 citations
,
October 2007 in “Journal of pineal research” This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.
9 citations
,
January 2005 in “Experimental dermatology” The researchers observed that normal murine hair follicles are direct targets for melatonin, with receptor expression varying throughout the hair cycle, suggesting melatonin's role in hair cycle control.
222 citations
,
January 2005 in “Endocrine journal” This article discusses the potential role of melatonin in protecting skin against stress and maintaining homeostasis, based on its local synthesis and various protective functions, but presents no new clinical results.
78 citations
,
February 2004 in “British Journal of Dermatology” This article reviews the potential impact of melatonin on hair growth, noting its benefits observed in animals, but reports no clinical results in humans to date.
