Real-World Evidence in Alopecia Areata Treatment: A Narrative Review

    October 2025 in “ Dermatologica Sinica ”
    C. C. Tsai, Feng‐Ling Lin, Ting-Ting Cheng, Yang Lo
    Studysummary This review highlights that although advancements in alopecia areata treatments, such as Janus kinase inhibitors and combination therapies, show promise, further research is necessary to validate their long-term safety and efficacy.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.lww.com →
    Discuss this study in the Community →

    Research cited in this study 60

    1. Taiwanese Dermatological Association Consensus on the Diagnosis and Management of Alopecia Areata Dermatologica Sinica · 2025
    2. Impact of Previous Alopecia Areata Treatment on Efficacy Responses Up to Week 48 Following Ritlecitinib Treatment: A Post Hoc Analysis Dermatology and Therapy · 2024
    3. Baricitinib Withdrawal and Retreatment in Patients With Severe Alopecia Areata JAMA Dermatology · 2024
    4. Dupilumab Induces Hair Regrowth in Pediatric Alopecia Areata: A Real-World, Single-Center Observational Study Archives of Dermatological Research · 2024
    5. Real-World Effectiveness and Safety of Tofacitinib for Alopecia Areata: A Retrospective Cohort Study of 202 Patients Australasian Journal of Dermatology · 2024
    6. The Role of Laser and Energy-Assisted Drug Delivery in the Treatment of Alopecia Lasers in Medical Science · 2024
    7. Dupilumab Therapy for Alopecia Areata: A Case Series and Review of the Literature Journal of Dermatological Treatment · 2024
    8. Treatments for Moderate-to-Severe Alopecia Areata: A Systematic Narrative Review Dermatology and therapy · 2023
    9. Effectiveness of Tofacitinib in Pre-Adolescent Alopecia Areata: A Retrospective Case Series and Literature Review Acta dermato-venereologica · 2023
    10. Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data Dermatology and Therapy · 2023
    11. Baricitinib: A Review in Severe Alopecia Areata American Journal of Clinical Dermatology · 2023
    12. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    13. Response to Ritlecitinib Treatment Based on Salt Improvement Scores in Patients With Alopecia Areata: Post Hoc Analysis of the Allegro Phase 2b/3 Study ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    14. Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial The Lancet · 2023
    15. Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata Over 52 Weeks in Phase III Trials American Journal of Clinical Dermatology · 2023
    16. Effect of Fractional Laser Alone or in Combination on Alopecia Areata: A Systematic Review and Meta-Analysis Journal of cosmetic dermatology · 2023
    17. Hydroxychloroquine for Granuloma Annulare: A Case Report on Secondary Hair Growth in Alopecia Universalis SAGE Open Medical Case Reports · 2023
    18. Use of Hydroxychloroquine in Hair Disorders Skin Appendage Disorders · 2023
    19. Comparative Study Between Topical Application of Triamcinolone Acetonide After Fractional Carbon Dioxide Laser Versus Microneedling in the Treatment of Resistant Alopecia Areata Dermatologic Therapy · 2022
    20. Baricitinib in Alopecia Areata New England Journal of Medicine · 2022
    21. Alopecia Areata and Dexamethasone Mini-Pulse Therapy: A Prospective Cohort Study on Real World Evidence and Factors Related to Successful Response Journal of Clinical Medicine · 2022
    22. Maintenance, Withdrawal, and Re-Treatment with Ritlecitinib and Brepocitinib in Patients with Alopecia Areata in a Single-Blind Extension of a Phase 2a Randomized Clinical Trial Journal of the American Academy of Dermatology · 2021
    23. Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2021
    24. Alopecia Universalis Associated With Hyperthyroidism Treated With Azathioprine And Hydroxychloroquine: A Case Report Journal of Nepal Medical Association · 2021
    25. Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study Journal of The American Academy of Dermatology · 2021
    26. Treatment of Pediatric Alopecia Areata: A Systematic Review Journal of the American Academy of Dermatology · 2021
    27. Dupilumab: A Review of Present Indications and Off-Label Uses Journal of investigational allergology & clinical immunology · 2021
    28. Dupilumab Therapy for Alopecia Areata in Pediatric Patients with Concomitant Atopic Dermatitis Journal of the American Academy of Dermatology · 2021
    29. Cyclosporine With and Without Systemic Corticosteroids in Treatment of Alopecia Areata: A Systematic Review Dermatology and therapy · 2020
    30. Efficacy and Safety of Tofacitinib Therapy in Asian Patients with Severe Alopecia Areata Dermatologica Sinica · 2020
    31. Efficacy of Different Concentrations of Intralesional Triamcinolone Acetonide for Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2019
    32. Early Onset of Alopecia Areata After Dupilumab Introduction in a Patient With Atopic Dermatitis European Journal of Dermatology · 2019
    33. Alopecia Areata in 2 Patients Treated with Dupilumab: New Onset and Worsening JAAD Case Reports · 2019
    34. Cyclosporine for Moderate-to-Severe Alopecia Areata: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety Journal of the American Academy of Dermatology · 2019
    35. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018
    36. Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata JAMA Dermatology · 2018
    37. Alopecia Areata Treated With Hydroxychloroquine: A Retrospective Study of Nine Pediatric Cases Pediatric dermatology · 2018
    38. Alopecia Areata After Dupilumab for Atopic Dermatitis JAAD case reports · 2018
    39. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    40. Tofacitinib 2% Ointment, a Topical Janus Kinase Inhibitor, for the Treatment of Alopecia Areata: A Pilot Study of 10 Patients Journal of the American Academy of Dermatology · 2017
    41. Oral Tofacitinib Monotherapy in Korean Patients with Refractory Moderate-to-Severe Alopecia Areata: A Case Series Journal of the American Academy of Dermatology · 2017
    42. Best Dilution of the Best Corticosteroid for Intralesional Injection in the Treatment of Localized Alopecia Areata in Adults Journal of dermatological treatment · 2017
    43. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    44. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    45. Multiple Courses of Pulse Corticosteroid Therapy for Alopecia Areata The Journal of Dermatology · 2016
    46. A Comparative Study of Oral Cyclosporine and Betamethasone Minipulse Therapy in the Treatment of Alopecia Areata Annals of dermatology/Annals of Dermatology · 2016
    47. Combined Oral Pulse and Topical Corticosteroid Therapy for Severe Alopecia Areata in Children: A Long-Term Follow-Up Study Dermatologic therapy · 2015
    48. Benefit of Different Concentrations of Intralesional Triamcinolone Acetonide in Alopecia Areata: An Intrasubject Pilot Study Journal of the American Academy of Dermatology · 2015
    49. Excimer Lamp as an Effective Alternative Treatment for Severe Alopecia Areata Dermatologica sinica/Zhōnghuá pífūkē yīxué zázhì · 2014
    50. How Effective Is Intralesional Injection of Triamcinolone Acetonide Compared with Topical Treatments in Inducing and Maintaining Hair Growth in Patients with Alopecia Areata? A Critically Appraised Topic British journal of dermatology/British journal of dermatology, Supplement · 2014
    51. Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children JAMA dermatology · 2013
    52. The Effect of Oral Cyclosporine in the Treatment of Severe Alopecia Areata Cutaneous and ocular toxicology · 2013
    53. Pulse Corticosteroid Therapy for Alopecia Areata in Children: A Retrospective Study Dermatology · 2013
    54. Combination Therapy with Cyclosporine and Psoralen Plus Ultraviolet A in Patients with Severe Alopecia Areata: A Retrospective Study with a Self-Controlled Design Annals of dermatology/Annals of Dermatology · 2013
    55. An Update on Alopecia Areata Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics · 2009
    56. Treatment of Persistent Alopecia Areata with Sulfasalazine International Journal of Dermatology · 2008
    57. Efficacy And Safety Of A New Clobetasol Propionate 0.05% Foam In Alopecia Areata: A Randomized, Double-Blind Placebo-Controlled Trial Journal of the European Academy of Dermatology and Venereology · 2006
    58. 308-Nm Excimer Laser Therapy in Alopecia Areata Journal of the American Academy of Dermatology · 2004
    59. The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians International Journal of Dermatology · 2002
    60. Sulfasalazine for Alopecia Areata Journal of the American Academy of Dermatology · 2002