Image

    Baricitinib: A Review in Severe Alopecia Areata

    Simon Fung, Matt Shirley
    Studysummary In two phase 3 clinical trials, this study found that adults with severe alopecia areata receiving baricitinib experienced significant hair regrowth on the scalp, eyebrows, and eyelashes over 36 weeks compared to placebo, although longer-term data are needed to fully assess benefits and risks.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on figshare.com →
    Discuss this study in the Community →

    Research cited in this study 18

    1. Safety Analysis of Baricitinib in Adult Patients With Severe Alopecia Areata From Two Randomized Clinical Trials Over a Median of 1.6 Years and Up to 3.6 Years of Exposure Journal of the American Academy of Dermatology · 2023
    2. Improvements in Health-Related Quality of Life and Psychological Symptoms in Patients With Severe Alopecia Areata Achieving Scalp Hair Regrowth: Results From Two Randomized Controlled Trials Journal of the American Academy of Dermatology · 2023
    3. Efficacy in Subgroups Related to Disease Characteristics in Patients with Alopecia Areata from BRAVE-AA1 and BRAVE-AA2 Journal of the American Academy of Dermatology · 2023
    4. Outcomes of Down-Titration in Patients with Severe Scalp Alopecia Areata Treated with Baricitinib 4 Mg: Week 104 Data from BRAVE-AA2 Journal of The American Academy of Dermatology · 2023
    5. Scalp Hair Regrowth Is Associated With Improvements in Health-Related Quality of Life and Psychological Symptoms in Patients With Severe Alopecia Areata: Results From Two Randomized Controlled Trials SKIN The Journal of Cutaneous Medicine · 2023
    6. Eyebrows and Eyelashes Regrowth Across Different SALT Response Thresholds in Patients with Alopecia Areata: Outcomes from the BRAVE AA Clinical Program SKIN The Journal of Cutaneous Medicine · 2023
    7. Trajectories for Scalp Hair Regrowth in Patients With Severe Alopecia Areata Treated With Baricitinib Skin · 2023
    8. Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata Over 52 Weeks in Phase III Trials American Journal of Clinical Dermatology · 2023
    9. Integrated Safety Analysis of Baricitinib in Adults With Severe Alopecia Areata From Two Randomized Clinical Trials British journal of dermatology/British journal of dermatology, Supplement · 2022
    10. Efficacy and Safety of Baricitinib in Adult Patients With Severe Alopecia Areata With or Without an Atopic Background From Two Randomized, Placebo-Controlled, Phase 3 Trials Journal of the American Academy of Dermatology · 2022
    11. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    12. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    13. Alopecia Areata: Current Understanding and Management Journal der Deutschen Dermatologischen Gesellschaft · 2022
    14. Alopecia Areata Treatment Patterns, Healthcare Resource Utilization, and Comorbidities in the US Population Using Insurance Claims Advances in Therapy · 2021
    15. Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study Journal of The American Academy of Dermatology · 2021
    16. A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021
    17. The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials British Journal of Dermatology · 2020
    18. Epidemiology and Burden of Alopecia Areata: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2015

    Related research 6

    1. The Usefulness and Wellbeing of Tofacitinib in the Treatment of Alopecia Areata Journal of Armed Forces Medical College, Bangladesh · 2022
    2. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    3. Alopecia Areata Universalis in a Dog Veterinary dermatology · 2015
    4. PUVA Treatment of Alopecia Areata Totalis and Universalis: A Retrospective Study Australasian journal of dermatology · 2003
    5. Cyclosporine Combination Therapy in Alopecia Areata Linchuang pifuke zazhi · 2002
    6. Hypertrichosis Due to Minoxidil British Journal of Dermatology · 1979