Outcomes of Down-Titration in Patients with Severe Scalp Alopecia Areata Treated with Baricitinib 4 Mg: Week 104 Data from BRAVE-AA2

    September 2023 in “ Journal of The American Academy of Dermatology ”
    Brett King, Manabu Ohyama, Maryanne M. Senna, Jerry Shapiro, Yves Dutronc, Wen‐Chi Wu, Guanglei Yu, Yuxin Ding, Chiara Chiasserini, Bianca Maria Piraccini
    Image of study
    TLDR Reducing the dose of Baricitinib to 2mg led to a loss of hair regrowth benefits in nearly half of the patients by Week-104.
    The study "Outcomes of Down-Titration in Patients with Severe Scalp Alopecia Areata Treated with Baricitinib 4 Mg: Week 104 Data from BRAVE-AA2" involved 546 adults with severe alopecia areata (AA). The study found that Baricitinib, an oral Janus kinase 1/2 inhibitor, was superior to a placebo in achieving hair regrowth in patients with severe AA at Week-36. At Week-52, 86 out of 234 patients initially treated with 4mg of Baricitinib were responders. These responders were then rerandomized to either stay on 4mg or down-titrate to 2mg. By Week-104, 90.2% of the responders who remained on 4mg maintained a Severity of Alopecia Tool (SALT) score of ≤20, indicating successful treatment. However, 45.2% of patients who down-titrated to 2mg experienced a loss of treatment benefit by Week-104. The study concludes that while these data help inform decisions on down-titration, more research is needed to better define the timing and conditions for successful down-titration.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Olumiant active ingredient Baricitinib

      in Research/Science  1 upvotes 1 year ago
      The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

    Similar Research

    5 / 1000+ results