Integrated Safety Analysis of Baricitinib in Adults With Severe Alopecia Areata From Two Randomized Clinical Trials
November 2022
in “
British journal of dermatology/British journal of dermatology, Supplement
”
baricitinib JAK1/JAK2 inhibitor alopecia areata BRAVE-AA1 BRAVE-AA2 treatment-emergent adverse events upper respiratory tract infection nasopharyngitis headache acne elevated blood creatine phosphokinase serious infections herpes zoster major adverse cardiovascular event pulmonary embolism malignancies nonmelanoma skin cancer gastrointestinal perforation JAK inhibitor AA TEAEs CPK shingles MACE PE skin cancer
Studysummary In this analysis, safety data from two clinical trials showed that baricitinib for severe alopecia areata had predictable side effects like infections and elevated CPK, with some serious adverse events noted at low incidence rates; no deaths were reported.
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