Improvements in Health-Related Quality of Life and Psychological Symptoms in Patients With Severe Alopecia Areata Achieving Scalp Hair Regrowth: Results From Two Randomized Controlled Trials

    Brittany G. Craiglow, Yang Won Lee, Sergio Vañó‐Galván, Alexander Egeberg, Yves Dutronc, Frédérick Durand, Evangeline Pierce, Yuxin Ding, Yunfei Chen, Arash Mostaghimi
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    TLDR Baricitinib helps regrow hair and improves quality of life and mental health in severe alopecia areata patients.
    The document reports on two phase 3 randomized controlled trials (BRAVE-AA1/2) that evaluated the efficacy of Baricitinib in patients with severe alopecia areata (AA). The trials demonstrated that Baricitinib significantly improved scalp hair regrowth. Additionally, these improvements were associated with enhanced health-related quality of life (HRQoL) and reduced psychological symptoms in the patients. The study underscores the importance of addressing both physical and psychological aspects in the treatment of severe AA. The research was fully sponsored by Eli Lilly and Company.
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      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Should I get transplant #4 or just shave my head?

      in Transplants  169 upvotes 3 months ago
      A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

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