Improvements in Health-Related Quality of Life and Psychological Symptoms in Patients With Severe Alopecia Areata Achieving Scalp Hair Regrowth: Results From Two Randomized Controlled Trials

September 2023 in “ Journal of the American Academy of Dermatology ”

Brittany G. Craiglow, Yang Won Lee, Sergio Vañó‐Galván, Alexander Egeberg, Yves Dutronc, Frédérick Durand, Evangeline Pierce, Yuxin Ding, Yunfei Chen, Arash Mostaghimi

alopecia areata Baricitinib scalp hair regrowth health-related quality of life psychological symptoms AA HRQoL

TLDR Baricitinib helps regrow hair and improves quality of life and mental health in severe alopecia areata patients.

The document reports on two phase 3 randomized controlled trials (BRAVE-AA1/2) that evaluated the efficacy of Baricitinib in patients with severe alopecia areata (AA). The trials demonstrated that Baricitinib significantly improved scalp hair regrowth. Additionally, these improvements were associated with enhanced health-related quality of life (HRQoL) and reduced psychological symptoms in the patients. The study underscores the importance of addressing both physical and psychological aspects in the treatment of severe AA. The research was fully sponsored by Eli Lilly and Company.

View this study on jaad.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 862 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community What else is good. Besides the big 3.

in Chat 34 upvotes 4 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Should I get transplant #4 or just shave my head?

in Transplants 173 upvotes 6 months ago

A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

community Anyone else taking Litfulo (ritlecitinib) to treat their alopecia?

in Treatment 5 upvotes 1 year ago

A user diagnosed with Alopecia Areata started using Litfulo (ritlecitinib), kenalog shots, and mometasone furoate 0.1%. They shaved their head and are seeking others' experiences with Litfulo.

community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

in Research/Science 2 years ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

Related Research

6 / 6 results

research Baricitinib Results in Eyebrow and Eyelash Growth in Patients With Alopecia Areata Who Do Not Achieve 20% or Less Scalp Hair Loss

1 citations, September 2022 in “Journal of The American Academy of Dermatology”

Baricitinib helps grow eyebrows and eyelashes in severe alopecia areata patients.

research Sensitive Scalp: An Epidemiologic Study in Patients with Hair Loss

1 citations, January 2022 in “Dermatology Reports”

Many people with hair loss, especially those with telogen effluvium and alopecia areata, often have a sensitive scalp.

research Time to Loss of Response for Dupilumab in Ophiasis-Pattern Alopecia Areata

2 citations, September 2021 in “JAAD case reports”

Dupilumab helped a woman with severe hair loss regrow her hair quickly and maintain it for six months after stopping treatment.

research A Clinico-Epidemiological Study of Scalp Hair Loss in Children (0–18 Years) in Kota Region, South-East Rajasthan

6 citations, January 2019 in “Indian Journal of Dermatology”

About 12% of children in Kota, Rajasthan, experience hair loss, mainly due to fungal infections, with early treatment advised to prevent worsening.

research Topical and Intralesional Therapies for Alopecia Areata

36 citations, May 2011 in “Dermatologic therapy”

No treatments fully cure or prevent alopecia areata; some help but have side effects or need more research.

research Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases

109 citations, May 2011 in “Dermatologic Therapy”

Alopecia areata is a type of hair loss that can lead to complete baldness, often associated with other autoimmune conditions, and half of the cases may see hair return within a year.