Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data

    September 2023 in “ Dermatology and Therapy ”
    Axel De Greef, Romane Thirion, Pierre‐Dominique Ghislain, Marie Baeck
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    TLDR Baricitinib effectively regrows hair in most people with severe alopecia, especially those with patchy hair loss, but hair may fall out again if treatment stops.
    A retrospective study of 19 adults with severe alopecia areata (AA) treated with baricitinib, an oral Janus kinase 1 and 2 inhibitor, over 13 months showed hair regrowth in nearly 90% of patients between 4 and 16 weeks after starting treatment. By the end of the follow-up, over 70% of patients, and specifically 100% of patients with patchy AA, achieved a Severity of Alopecia Tool (SALT) score of ≤ 20, indicating significant hair regrowth. Almost half of the patients, mostly with patchy AA, showed complete hair regrowth within a median treatment time of 8.5 months. However, baricitinib was discontinued in three patients who had total hair regrowth, two of whom relapsed. No serious adverse events were reported, with lipid changes being the most frequent adverse event. The study concluded that baricitinib is effective in treating AA, particularly the patchy phenotype, but there is a risk of relapse after discontinuation.
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      community What else is good. Besides the big 3.

      in Chat  34 upvotes 2 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Olumiant active ingredient Baricitinib

      in Research/Science  1 upvotes 2 years ago
      The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

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