Borate-Modified Recombinant Type XVII Collagen Microneedles Loaded with IGF-1 for the Treatment of Androgenetic Alopecia

    May 2025 in “ International Journal of Biological Macromolecules ”
    Xing Zheng, Wenhao Yang, Chen Zhao … Jianhao Wang
    Studysummary In this study, an innovative microneedle platform loaded with IGF-1 and modified collagen was reported to significantly promote hair regeneration, enhance neovascularization, and reduce inflammation in a mouse model of androgenetic alopecia, outperforming the commonly used minoxidil treatment.
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    Research cited in this study 23

    1. Platinum Nanozyme-Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment Small Methods · 2024
    2. Hybrid Hair Follicle Stem Cell Extracellular Vesicles Co-Delivering Finasteride and Gold Nanoparticles for Androgenetic Alopecia Treatment Journal of Controlled Release · 2024
    3. Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging Journal of Advanced Research · 2024
    4. Hydrogel Forming Microneedles Loaded With VEGF and Ritlecitinib/Polyhydroxyalkanoates Nanoparticles for Mini-Invasive Androgenetic Alopecia Treatment Bioactive materials · 2024
    5. Microneedle Delivery Platform Integrated With Codelivery Nanoliposomes for Effective and Safe Androgenetic Alopecia Treatment ACS Applied Materials & Interfaces · 2024
    6. Traditional Scraping Combined with Copper-Curcumin Nanoparticle Oleogel for Therapy of Androgenic Alopecia Advanced Healthcare Materials · 2024
    7. Nitric Oxide Synergizes Minoxidil Delivered by Transdermal Hyaluronic Acid Liposomes for Multimodal Androgenetic Alopecia Therapy Bioactive Materials · 2023
    8. The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia International Journal of Biological Sciences · 2023
    9. Efficacy of Autologous Stromal Vascular Fraction Injection in the Treatment of Androgenic Alopecia Archives of Dermatological Research · 2022
    10. Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/Beta-Catenin and BMP Signaling Pathways International Journal of Molecular Sciences · 2022
    11. Conditioned Media-Integrated Microneedles for Hair Regeneration Through Perifollicular Angiogenesis Journal of Controlled Release · 2022
    12. Hair Follicle-Targeting Drug Delivery Strategies for the Management of Hair Follicle-Associated Disorders Asian Journal of Pharmaceutical Sciences · 2022
    13. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    14. Targeting the Stem Cell Niche: Role of Collagen XVII in Skin Aging and Wound Repair Theranostics · 2022
    15. Microneedling and Its Use in Hair Loss Disorders: A Systematic Review Dermatology and therapy · 2021
    16. Microneedling for Hair Loss Journal of Cosmetic Dermatology · 2021
    17. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    18. Safety and Efficacy of ALRV5XR in Women with Androgenetic Alopecia or Telogen Effluvium: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial EClinicalMedicine · 2021
    19. Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100 Journal of nanobiotechnology · 2021
    20. Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep Cell Death and Disease · 2020
    21. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    22. Microneedles in the Clinic: A Comprehensive Review of Clinical Studies and Applications Journal of controlled release · 2017
    23. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016