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research Borate-modified recombinant type XVII collagen microneedles loaded with IGF-1 for the treatment of androgenetic alopecia

May 2025 in “International Journal of Biological Macromolecules”

In this study, an innovative microneedle platform loaded with IGF-1 and modified collagen was reported to significantly promote hair regeneration, enhance neovascularization, and reduce inflammation in a mouse model of androgenetic alopecia, outperforming the commonly used minoxidil treatment.

research Collagen XVIIα1 in skin and hair aging: Mechanisms, stem cell niche regulation, and translational strategies

May 2026 in “Journal of Dermatological Science”

This review highlights that collagen XVIIα1's role in maintaining dermal-epidermal junction integrity and hair follicle stem cell maintenance is compromised with age due to reduced levels and increased processing, potentially affecting skin and hair aging.

research Beyond Expectations

70 citations , January 2014 in “International review of cell and molecular biology”

This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.

Encapsulation In Cyclodextrins Of Compounds With Activity Against Male Androgenetic Alopecia

research Encapsulación en ciclodextrinas de compuestos con actividad frente a la alopecia androgénica masculina.

January 2021 in “RIUCAM”

This research focused on formulating finasteride, dutasteride, and minoxidil with cyclodextrins to enhance their solubility and skin penetration for topical use, potentially reducing scalp irritation from current alcohol-based preparations.

research Recent Progress of Dopamine-Modified Tissue Adhesives for Biomedical Applications in Underwater Environments

March 2026 in “Tissue Engineering and Regenerative Medicine”

In this review, the authors discuss recent advancements in underwater adhesion technologies, specifically highlighting mussel-inspired catechol-based adhesives, which offer strong underwater bonding through various interfacial interactions and the influence of dopamine-modified polymeric tissue adhesives.

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learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Minoxidil

What microneedling is? Microneedling is a procedure that uses fine needles to stimulate collagen production and improve skin and hair health.

learn Hydrolyzed Collagen

learn hydrolyzed fish collagen

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community Dissolving microneedles made from starch+pectin with minoxidil or quercetin as active ingredient - possible?

2 upvotes 3 years ago

community Opinions on best microneedling protocol? Some thoughts...

11 upvotes 3 years ago

Microneedling can enhance hair growth by improving minoxidil absorption and stimulating blood flow. Users discuss optimal needle depths, with some favoring shallow frequent needling for better absorption and others preferring deeper needling for stem cell activation.

community Y'all, we have got to come to a consensus on the specifics of microneedling.

27 upvotes 4 years ago

Microneedling can promote hair growth, but there is uncertainty about the best practices, including needle length, device, and session frequency. Users discuss using needle lengths between 0.5mm and 1.5mm, with some experiencing pinpoint bleeding, and emphasize the need for more reliable resources and guidelines.

community What are people mixing peptides with for micro needling?

2 upvotes 1 year ago

Peptides are being considered for microneedling, with suggestions to mix them with a water-based serum like Estee Lauder night repair, but not with water. A user switched from minoxidil and derma roller to a brand called Mikro for its cleaner application and natural ingredients.

community What type of microneedling device should I use?

in Microneedling 4 upvotes 1 year ago

Use a stamp or roller for microneedling; stamps are preferred to avoid hair pulling. Clean tools with alcohol to prevent infection, and replace stamps every 4-6 uses.

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