Borate-Modified Recombinant Type XVII Collagen Microneedles Loaded with IGF-1 for the Treatment of Androgenetic Alopecia

    May 2025 in “ International Journal of Biological Macromolecules ”
    Xing Zheng, Wenhao Yang, Chen Zhao, Yuhui Wang, Xiaolian Jiang, Qian Song, Yun Chu, Xia Jiang, Cheng Wang, Jianhao Wang
    TLDR A new microneedle treatment shows promise for better hair regrowth in androgenetic alopecia.
    The study presents a novel treatment for androgenetic alopecia (AGA) using borate-modified recombinant type XVII collagen microneedles (I-mCOL17 MNs) loaded with IGF-1. These microneedles are designed to enhance the delivery and efficacy of growth factors by overcoming skin barriers and responding to changes in the microenvironment. In murine models, the I-mCOL17 MNs demonstrated superior performance compared to minoxidil, promoting hair regeneration, enhancing neovascularization, and reducing inflammation. This innovative approach offers a safer and more efficient strategy for AGA treatment, providing new hope for patients with this common form of hair loss.
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