Collagen XVIIα1 in Skin and Hair Aging: Mechanisms, Stem Cell Niche Regulation, and Translational Strategies

    May 2026 in “ Journal of Dermatological Science ”
    Zixuan He, Fenglin Zhuo
    Studysummary This review highlights that collagen XVIIα1's role in maintaining dermal-epidermal junction integrity and hair follicle stem cell maintenance is compromised with age due to reduced levels and increased processing, potentially affecting skin and hair aging.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jdsjournal.com →
    Discuss this study in the Community →

    Research cited in this study 8

    1. Borate-Modified Recombinant Type XVII Collagen Microneedles Loaded with IGF-1 for the Treatment of Androgenetic Alopecia International Journal of Biological Macromolecules · 2025
    2. Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia Acta Biomaterialia · 2025
    3. Novel Strategy for Hair Regeneration: Exosomes and Collagenous Sequences of Human A1(XVII) Chain Enhance Hair Follicle Stem Cell Activity by Regulating the Hsa-Novel-238a-CASP9 Axis Experimental Cell Research · 2025
    4. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    5. Life Before and Beyond Blistering: The Role of Collagen XVII in Epidermal Physiology Experimental Dermatology · 2018
    6. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    7. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    8. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011