Cytochalasin B-Induced Adipose Stem Cell-Derived Nanovesicles Promote Hair Follicle Regeneration via Activation of the Beta-Catenin Signaling Pathway

    Li Wang, Yiwen LIU, Peiyun CAI … Lei CAO
    Studysummary This study found that adipose stem cell-derived nanovesicles promoted dermal papilla cell proliferation, migration, and anti-apoptotic effects in vitro and enhanced hair follicle cycle progression in mice, primarily through activation of the β-catenin signaling pathway.
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    Research cited in this study 29

    1. Platelet-Derived Extracellular Vesicles Promote Hair Follicle Growth Through Beta-Catenin Signaling Pathway Platelets · 2025
    2. Dahuang-Gancao Decoction Ameliorates Testosterone-Induced Androgenetic Alopecia in Mice Journal of Ethnopharmacology · 2025
    3. Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway International Journal of Molecular Sciences · 2024
    4. Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells Stem Cell Research & Therapy · 2024
    5. Optimized Depilation Method and Comparative Analysis of Hair Growth Cycle in Mouse Strains Animals · 2024
    6. Exosomes for Hair Growth and Regeneration Journal of Bioscience and Bioengineering · 2023
    7. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway Stem Cells International · 2023
    8. Mesenchymal Stromal Cell-Derived Magnetic Nanovesicles for Enhanced Skin Retention and Hair Follicle Growth Cytotherapy · 2023
    9. Medicinal and Edible Plant Allium Macrostemon Bunge for the Treatment of Testosterone-Induced Androgenetic Alopecia in Mice Journal of Ethnopharmacology · 2023
    10. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    11. Natural Compounds Used For Treating Hair Loss Current Pharmaceutical Design · 2023
    12. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    13. Activation of Camp Signaling in Response to Alpha-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells International journal of molecular sciences · 2022
    14. Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics Frontiers in cell and developmental biology · 2022
    15. Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia Journal of immunology research · 2022
    16. Engineered Extracellular Vesicle Mimetics from Macrophage Promotes Hair Growth in Mice and Human Hair Follicle Growth Experimental cell research · 2021
    17. Platelet-Rich Plasma for Androgenic Alopecia: A Randomized, Placebo-Controlled, Double-Blind Study and Combined Mice Model Experiment Journal of Cosmetic Dermatology · 2021
    18. Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100 Journal of nanobiotechnology · 2021
    19. MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020
    20. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020
    21. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    22. Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells · 2020
    23. Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin Stem cells · 2019
    24. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    25. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    26. Differential Expression of Proteins Associated with the Hair Follicle Cycle: Proteomics and Bioinformatics Analyses PLOS ONE · 2016
    27. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    28. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    29. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013