A Study on the Regulation of Dermal Papilla Cells Proliferation and Anti-Androgen Mechanism of Terminalia Bellirica: Verification Based on Inhibition of 5α-Reductase and Cell Model

    July 2026 in “ Journal of Dermatologic Science and Cosmetic Technology ”
    Huan Chen, Tianyang Feng, Wenbo Wan … Liyong Du
    Studysummary This study found that extracts from Terminalia bellirica enhanced dermal papilla cell viability, inhibited androgen-related pathways, and stimulated hair regrowth in a mouse model, suggesting potential for treating androgenetic alopecia through multi-target mechanisms.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 33

    1. Restoration of Follicular β-Catenin Signaling by Mesenchymal Stem Cells Promotes Hair Growth in Mice with Androgenetic Alopecia Stem Cell Research & Therapy · 2024
    2. Cyanidin-3-O-Glucoside And Its Derivative Vitisin A Alleviate Androgenetic Alopecia By Exerting Anti-Androgen Effect And Inhibiting Dermal Papilla Cell Apoptosis European Journal of Pharmacology · 2023
    3. Favorable Effect of Herbal Extract on Androgenic Alopecia: A Case Report Medicine · 2023
    4. Androgenetic Alopecia: An Update JAAD International · 2023
    5. The In Vivo and In Vitro Effects of Terminalia Bellirica Fruit Extract on Testosterone-Induced Hair Loss Journal of Microbiology and Biotechnology · 2023
    6. Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair Clinica Chimica Acta · 2023
    7. Ginsenoside CK Inhibits Androgenetic Alopecia by Regulating Wnt/Beta-Catenin and P53 Signaling Pathways in AGA Mice Food frontiers · 2023
    8. Action Mechanism of Extracts from Cerasus Serrulata Flower for Hair-Blackening in C57BL/6 Mice Pharmacognosy Magazine · 2023
    9. Telogen Effluvium, Diagnosis and Management: A Narrative Review International Journal of Biomedicine · 2023
    10. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    11. Ficus Benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation Frontiers in Pharmacology · 2021
    12. Liposomal Honokiol Promotes Hair Growth Via Activating Wnt3a/β-Catenin Signaling Pathway and Downregulating TGF-β1 in C57BL/6N Mice Biomedicine & Pharmacotherapy · 2021
    13. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021
    14. Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase Biomedicine & Pharmacotherapy · 2021
    15. Evaluating Hair Growth Promoting Effects of Candidate Substances: A Review of Research Methods Journal of Dermatological Science · 2019
    16. Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay BMC Complementary and Alternative Medicine · 2015
    17. Treatment Options for Alopecia Expert Opinion on Pharmacotherapy · 2015
    18. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    19. Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo Growth Hormone & IGF Research · 2014
    20. A Role of Placental Growth Factor in Hair Growth Journal of dermatological science · 2014
    21. Dermal Papilla Cells Induce Keratinocyte Tubulogenesis in Culture Histochemistry and cell biology · 2010
    22. Big Head? Bald Head! Skull Expansion: Alternative Model for the Primary Mechanism of Androgenetic Alopecia Medical Hypotheses · 2008
    23. The Hair Cycle Journal of Cell Science · 2006
    24. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    25. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    26. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004
    27. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    28. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    29. The Role of VEGF and Thrombospondins in Skin Angiogenesis Journal of Dermatological Science · 2000
    30. Expression of Vascular Endothelial Growth Factor (VEGF) in Various Compartments of the Human Hair Follicle Archives of Dermatological Research · 1998
    31. Finasteride: The First 5α-Reductase Inhibitor Pharmacotherapy · 1993
    32. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    33. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992