Action Mechanism of Extracts from Cerasus Serrulata Flower for Hair-Blackening in C57BL/6 Mice

April 2023 in “ Pharmacognosy Magazine ”

Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Baoshan Rong, Xiaomin Zheng, Siyang Zhu, Xian Xu, Yong Ai, Lanyue Zhang, Tinggang He

Cerasus serrulata CSE β-catenin vascular endothelial growth factor VEGF hair blackening premature greying

TLDR Cerasus serrulata flower extracts can help turn grey hair black again.

The study explores the hair-blacking effects of Cerasus serrulata flower extracts (CSE) in C57BL/6 mice, demonstrating that CSE significantly enhances β-catenin and VEGF expression, promoting hair growth and pigmentation. The research, involving 15 mice per group, suggests CSE as a potential treatment for premature greying, likely through the VEGF pathway. CSE was found to be non-toxic up to 2000 mg/kg, with the 5% concentration showing the most significant effects. However, higher concentrations (10%) inhibited VEGF expression, indicating the need for further research to fully understand the molecular mechanisms.

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