Deciphering Principles of Morphogenesis from Temporal and Spatial Patterns on the Integument
April 2015
in “
Developmental Dynamics
”
morphogenesis integument system feathers hairs cellular proliferation cellular differentiation Wnt pathway BMP pathway Notch pathway activator/inhibitor model Turing diffusion-driven instability mechanical stress tissue patterning stem cells macro-environmental factors regenerative behavior genetic mechanisms epigenetic mechanisms SNP EphB2 gene ectodermal progenitors regenerative medicine skin system hair growth cell growth cell specialization Wnt signaling bone morphogenetic protein Notch signaling stem cell cycles environmental factors gene mechanisms epigenetic changes single nucleotide polymorphism EphB2 skin progenitors regeneration therapy
Studysummary This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.
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