Light exposure is crucial for health, helping prevent and treat illnesses.
15 citations
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August 2022 in “The Application of Clinical Genetics” ABCD1 gene mutations cause adrenomyeloneuropathy, leading to symptoms like limb weakness and spasticity, with management focusing on rehabilitation and spasticity treatment.
January 1969 in “Santes Creus: Boletín del Archivo Bibliográfico de Santes Creus” Planarians regenerate using conserved gene expression mechanisms, with runt-1 crucial for cell type specification.
March 2026 in “Cell Death Discovery” The review explores the pivotal role of the p63 gene in maintaining skin homeostasis and its involvement in skin diseases. It details the functions of its isoforms, TAp63 and ΔNp63, in regulating cell processes such as proliferation, differentiation, and stress responses. p63 is crucial for skin development, affecting epithelial fate, chromatin remodeling, cell adhesion, and barrier formation, and is involved in skin regeneration and differentiation through metabolic reprogramming and stem cell modulation. Mutations in p63 are associated with ectodermal dysplasia and other skin disorders, highlighting its significance in skin health. The review proposes that targeting p63 could offer therapeutic benefits for skin-related diseases.
39 citations
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January 2019 in “Cells” Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.