Transcriptome Profiling of Whisker Follicles in Methamphetamine Self-Administered Rats

    July 2018 in “ Scientific Reports ”
    Sang-Hoon Song, Won‐Jun Jang, Jihye Hwang, Byoungduck Park, Jung‐Hee Jang, Youngho Seo, Chae Ha Yang, Sooyeun Lee, Chul‐Ho Jeong
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    TLDR Methamphetamine affects gene expression in rat whisker follicles, with key genes linked to addiction.
    The study explored gene expression changes in whisker follicles of methamphetamine (MA) self-administered rats to understand MA addiction. Researchers identified 43 core genes potentially regulating MA reward and addiction, with Hsp90ab1, Akt1, and Src as top candidates. RNA sequencing revealed 1,890 transcripts and 666 genes with differential expression, highlighting pathways related to Alzheimer's disease and heparan sulfate biosynthesis. The study involved 12 rats, divided into control and MA groups, and emphasized the need for further research to compare whisker follicle and brain gene expression to fully understand MA addiction mechanisms.
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