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    Glossary SMAD4

    protein involved in TGF-beta signaling, affecting cell growth and differentiation

    SMAD4, also known as Mothers against decapentaplegic homolog 4, is a protein that plays a crucial role in the TGF-beta signaling pathway, which is involved in regulating cell growth, differentiation, and apoptosis. Mutations in the SMAD4 gene can lead to various medical conditions, including certain types of cancer and hereditary hemorrhagic telangiectasia.

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    Research 30 of 1000+

    1. Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development Developmental Cell · 2006 · 147 citations
    2. Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Stem Cell Research & Therapy · 2020 · 139 citations
    3. Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues The EMBO Journal · 2002 · 111 citations
    4. Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes Nucleic Acids Research · 2002 · 79 citations
    5. The 800-nm diode laser irradiation induces skin collagen synthesis by stimulating TGF-β/Smad signaling pathway Lasers in Medical Science · 2011 · 59 citations
    6. The Role of Smads in Skin Development 2008 · 59 citations
    7. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008 · 43 citations
    8. Smad1 and 5 but Not Smad8 Establish Stem Cell Quiescence Which Is Critical to Transform the Premature Hair Follicle During Morphogenesis Toward the Postnatal State Stem Cells · 2013 · 31 citations
    9. Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity Developmental Biology · 2008 · 28 citations
    10. Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells Journal of Dermatological Science · 2011 · 19 citations
    11. Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes Plastic and Reconstructive Surgery · 2007 · 16 citations
    12. The up‐regulation of 14‐3‐3 proteins in Smad4 deficient epidermis and hair follicles at catagen PROTEOMICS · 2008 · 14 citations
    13. miR‐203a‐3p promotes loureirin A‐induced hair follicle stem cells differentiation by targeting Smad1 ˜The œanatomical record · 2020 · 12 citations
    14. Live imaging of Smad2/3 signaling in mouse skin wound healing Wound repair and regeneration · 2007 · 12 citations
    15. Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma Oncotarget · 2018 · 11 citations
    16. All-trans-retinoic acid inhibits mink hair follicle growth via inhibiting proliferation and inducing apoptosis of dermal papilla cells through TGF-β2/Smad2/3 pathway Acta histochemica · 2020 · 10 citations
    17. From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation PeerJ · 2022 · 4 citations
    18. miR-370-3p Inhibited the Proliferation of Sheep Dermal Papilla Cells by Inhibiting the Expression of SMAD4 Cells · 2025 · 4 citations
    19. HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF‐β/Smad signaling pathway in CARASIL model mice Brain and Behavior · 2022 · 3 citations
    20. Polysulfonic acid mucopolysaccharide exerts anti scarring effect in rats through modulation of TGF β 1/Smad signaling pathway Tropical Journal of Pharmaceutical Research · 2023 · 1 citations
    21. Human bone marrow mesenchymal stem cells-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Research Square (Research Square) · 2020 · 1 citations
    22. Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation Cell Death Discovery · 2022 · 1 citations
    23. Exploring the Complexities of TGF-beta Signaling in Keloids: Beyond the Classical Smad Pathway International Journal of Molecular Sciences · 2026
    24. Kaempferol enhances hair growth by regulating JAK3/STAT6 and TGF-β/Smad signaling in human dermal papilla cells and a C57BL/6 mousemodel Records of Natural Products · 2025
    25. Human hair follicle mesenchymal stem cell-derived exosome attenuates UVB-induced photoaging via the miR-125b-5p/TGF-β1/Smad axis Biomaterials Research · 2024
    26. Data from Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients 2023
    27. Human bone marrow mesenchymal stem cells-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway Research Square (Research Square) · 2020
    28. 270 A novel small compound HPH-15 antagonizes TGF-β/Smad signaling and ameliorates experimental skin fibrosis Journal of Investigative Dermatology · 2017
    29. All-trans retinoic acid modulates proliferation and apoptosis of secondary hair follicle–dermal papilla cells in cashmere goats via the TGF-β2/Smad2/3 pathway Frontiers in Veterinary Science · 2026
    30. iTRAQ-based quantitative proteomics revealing the therapeutic mechanism of a medicinal and edible formula YH0618 in reducing doxorubicin-induced alopecia by targeting keratins and TGF-β/Smad3 pathway Heliyon · 2024