Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

    February 2007 in “ Plastic and Reconstructive Surgery ”
    Amy S. Colwell, Rodolfo Faudoa, Thomas M. Krummel … H. Peter Lorenz
    Studysummary This study found that keratinocytes show increased expression of the TGF-β system and collagen type I with age, suggesting a heightened profibrotic response during skin differentiation associated with scarring.
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    Research cited in this study 2

    1. Ontogenetic Transition in Fetal Wound Transforming Growth Factor-Beta Regulation Correlates with Collagen Organization American Journal of Pathology · 2003
    2. Confocal Microscopic Analysis of Scarless Repair in the Fetal Rat Plastic & Reconstructive Surgery · 2002