TLDR Smad2/3-dependent TGF-β signaling increases during wound healing.
The study utilized biophotonics and real-time imaging in transgenic mice to observe Smad2/3 signaling during skin wound healing. Two types of wounds were created: one sutured and one healing by secondary intention, with 8 samples each. Bioluminescence, indicating TGF-β signaling, increased post-wounding, peaking on day 17 at four times the baseline level (p < 0.05). Sutured wounds showed earlier peak activity compared to secondary healing wounds, though not statistically significant. Phospho-Smad2/3 was intensely stained in hair follicles. The study concluded that Smad2/3-dependent TGF-β signaling increased during wound healing, differing from other studies that reported elevated signaling immediately after wounding.
163 citations
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October 2001 in “EMBO journal” Overexpressing follistatin in mice delays wound healing and reduces scar size.
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October 1999 in “EMBO journal” Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.
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January 2012 in “Cell stem cell” TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
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December 2018 in “Immunity” Targeting TGFβ can improve skin immunity in older people.
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March 2022 in “Molecules” 5-Bromo-3,4-dihydroxybenzaldehyde could potentially help hair growth by activating certain cell pathways and inhibiting others.
