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research IGF1 and BM-MSC Incorporating Collagen-Chitosan Scaffolds Promote Wound Healing and Hair Follicle Regeneration

3 citations, January 2020 in “PubMed”

Adding insulin-like growth factor 1 and bone marrow-derived stem cells to a collagen-chitosan scaffold helps wounds heal faster and regrows hair follicles.

research Establishment of an Immortalized Mouse Dermal Papilla Cell Strain with Optimized Culture Strategy

3 citations, January 2018 in “PeerJ”

Researchers created a long-lasting mouse skin cell strain that may help with hair growth research and treatments.

research BFNB Enhances Hair Growth in C57BL/6 Mice Through the Induction of EGF and FGF7 Factors and the PI3K-AKT-Beta-Catenin Pathway

2 citations, July 2023 in “International Journal of Molecular Sciences”

BFNB could be a promising treatment for hair growth.

research Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production

2 citations, February 2023 in “International journal of molecular sciences”

Tetrathiomolybdate reduces hair growth marker in skin cells by boosting harmful oxygen molecules, but effects can be reversed.

research Effects of Baicalin on Alopecia and the Associated Mechanism

2 citations, November 2022 in “BioMed Research International”

Baicalin may help treat hair loss by promoting hair follicle growth and activating specific cellular pathways.

research 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA)

2 citations, June 2022 in “Cells”

3D cell cultures are better for testing hair growth treatments than 2D cultures.

research Effect of Hataedock Treatment on Epidermal Structure Maintenance Through Intervention in the Endocannabinoid System

2 citations, January 2020 in “Evidence-based Complementary and Alternative Medicine”

Hataedock treatment improved skin health and reduced atopic dermatitis symptoms by enhancing the skin barrier and reducing inflammation.

research 4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly Via Activating the NRF2/HO-1 Signalling Pathway

1 citations, March 2024 in “Journal of Cellular and Molecular Medicine”

4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.

research MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata

1 citations, December 2023 in “International journal of molecular sciences”

miR-199a-3p controls hair growth and is linked to alopecia areata.

research Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

1 citations, December 2023 in “Animals”

Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.

research The Anti-Muscle Atrophy Effects of Ishige Sinicola in LPS-Induced C2C12 Myotubes Through Antioxidant and Anti-Inflammatory Actions

1 citations, September 2023 in “Applied sciences (Basel)”

Ishige sinicola extract may help prevent muscle atrophy through its antioxidant and anti-inflammatory effects.

research CRABP2 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/Beta-Catenin Pathway

1 citations, June 2023 in “Animals”

CRABP2 helps increase the growth of cells important for hair growth by activating a specific growth pathway.

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

research Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

1 citations, February 2023 in “International Journal of Molecular Sciences”

Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.

Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

research Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

1 citations, October 2022 in “International Journal of Molecular Sciences”

Using healthy donor stem cells can potentially calm overactive immune cells and reduce inflammation in severe hair loss patients, offering a possible treatment method.

research Cucurbitacin Promotes Hair Growth in Mice by Inhibiting the Expression of Fibroblast Growth Factor 18

1 citations, October 2022 in “Annals of Translational Medicine”

Cucurbitacin helps mice grow hair by blocking a protein that stops hair growth.

research Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways

1 citations, July 2022 in “British Journal of Dermatology”

Targeting specific genes in certain pathways may help treat male pattern baldness.

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

1 citations, May 2022 in “Frontiers in Pharmacology”

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

research Thyroid Hormone Receptor Agonist Promotes Hair Growth in Mice

1 citations, February 2022 in “Clinical, Cosmetic and Investigational Dermatology”

TDM10842, a thyroid hormone receptor activator, was found to effectively promote hair growth in mice.

research Antioxidant and Antiproliferative Activity of Finasteride Against Glioblastoma Cells

1 citations, September 2021 in “Pharmaceutics”

High-dose finasteride may help treat glioblastoma but needs localized delivery for effectiveness.

research Hair Growth Promotion by Delta-Opioid Receptor Activation

1 citations, June 2021 in “Biomolecules & Therapeutics”

Activating δ-opioid receptors can help hair grow.

research Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin

January 2025 in “International Journal of Molecular Sciences”

This study explores the ligand-independent actions of the Vitamin D Receptor (VDR) in maintaining skin and hair follicle homeostasis using genetically modified rats. VDR knockout (KO) rats, which lack the VDR gene, showed alopecia, hyperkeratosis, and increased trans-epidermal water loss, indicating compromised skin barrier integrity. In contrast, mutant Vdr-R270L/H301Q rats, which cannot bind vitamin D, exhibited normal skin and hair conditions. The research highlights that non-liganded VDR is crucial for keratinocyte differentiation, proliferation, and apoptosis, particularly in hair follicles and the epidermis. The study identifies significant gene expression differences, with 10,015 differentially expressed genes in KO rats, and emphasizes the suppression of Wnt and Bmp signaling pathways, essential for hair cycle maintenance. These findings suggest that non-liganded VDR plays a critical role in skin and hair health, offering potential therapeutic targets for alopecia and skin disorders related to VDR deficiency.