Hair Growth Effect and the Mechanisms of Rosa Rugosa Extract in DHT-Induced Alopecia Mice Model

    Ha-Rim Kim, Jung Up Park, Seung-Hyeon Lee, Jae Young Park, Wonwoo Lee, Kyung-Min Choi, Seon‐Young Kim, Mi Hee Park
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    TLDR Rosa rugosa extract promotes hair growth and could be a natural treatment for hair loss.
    The study on Rosa rugosa extract (RWE) in a DHT-induced alopecia mouse model found that RWE significantly promotes hair growth. Mice treated with RWE showed increased hair length, thickness, and follicle numbers, with a higher percentage of follicles in the anagen phase. RWE enhanced the expression of growth-promoting factors like VEGF, EGF, and IGF-1, while reducing inhibitory factors such as DKK1 and IL-6. It also activated key signaling pathways, including ERK, AKT, and Wnt/β-catenin, crucial for hair follicle growth. These results suggest RWE as a promising natural therapy for hair loss and alopecia.
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