A Narrowed Look Into Plant-Derived Testosterone 5α-Reductase Inhibitors for Androgenetic Alopecia

May 2024 in “ Current perspectives on medicinal and aromatic plants ”

Nurten Abacı, İlkay Erdoğan Orhan

testosterone 5α-reductase inhibitors androgenetic alopecia DHT plant-derived inhibitors natural inhibitors testosterone dihydrotestosterone plant extracts synthetic drugs AGA natural treatments

TLDR Plant-based treatments might help with hair loss and have fewer side effects than synthetic drugs.

The study explores the potential of plant-derived inhibitors of testosterone 5α-reductase as treatments for androgenetic alopecia (AGA). It highlights that these natural inhibitors can reduce the conversion of testosterone to dihydrotestosterone (DHT), a key factor in AGA. The research reviews various plants and their extracts, noting their efficacy and safety profiles. The findings suggest that these plant-based treatments could offer a viable alternative to synthetic drugs, with fewer side effects. However, the study calls for more extensive clinical trials to confirm these preliminary results and establish standardized dosages.

View this study on dergipark.org.tr →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 156 upvotes 11 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Fats on your Head to Stop Hair Loss?

in Research/Science 138 upvotes 9 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 month ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community Natural Remedies: Polyphenols and Hair Loss

19 upvotes 5 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

Related Research

4 / 4 results

Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review

research Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review

January 2024 in “Brazilian Journal of Hair Health”

Some plant-based products might treat hair loss with fewer side effects than current medications.

research A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits

June 2019 in “Journal of Drug Delivery and Therapeutics”

Finasteride effectively treats hair loss and prostate issues with minimal side effects.

research Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

7 citations, August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

9 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”