A Narrowed Look Into Plant-Derived Testosterone 5α-Reductase Inhibitors for Androgenetic Alopecia

May 2024 in “ Current perspectives on medicinal and aromatic plants ”

Nurten Abacı, İlkay Erdoğan Orhan

testosterone 5α-reductase inhibitors androgenetic alopecia DHT plant-derived inhibitors natural inhibitors testosterone dihydrotestosterone plant extracts synthetic drugs AGA natural treatments

TLDR Plant-based treatments might help with hair loss and have fewer side effects than synthetic drugs.

The study explores the potential of plant-derived inhibitors of testosterone 5α-reductase as treatments for androgenetic alopecia (AGA). It highlights that these natural inhibitors can reduce the conversion of testosterone to dihydrotestosterone (DHT), a key factor in AGA. The research reviews various plants and their extracts, noting their efficacy and safety profiles. The findings suggest that these plant-based treatments could offer a viable alternative to synthetic drugs, with fewer side effects. However, the study calls for more extensive clinical trials to confirm these preliminary results and establish standardized dosages.

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