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research Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (Oryza sativa L. cv. Pieisu 1 CMU) for Cosmetic Application

18 citations , February 2023 in “Plants”

This study found that PES1CMU-defatted rice bran (DFRB) showed effective skin whitening and anti-aging properties comparable to standard treatments in cell models, suggesting its potential use in dermatocosmetics.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.

research A Natural Inhibitor, 1′S-1′-Acetoxychavicol Acetate, Against Testosterone-Induced Alopecia via NADPH Oxidase Regulation

May 2025 in “Molecules”

This study found that 1′S-1′-acetoxychavicol acetate from Alpinia galanga inhibits Nox isozymes and suppresses testosterone-induced hair loss in a mouse model of androgenetic alopecia.

research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

11 citations , December 2018 in “Assay and Drug Development Technologies”

This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.

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community Similar 5ar inhibitors to fin?

5 years ago

Natural vitamins like pumpkin seed oil, saw palmetto, and ecklonia cava are discussed for their potential to lower DHT levels. They may work similarly to finasteride but are significantly weaker.

community Pumpkin seed oil for hair loss. Has anyone actually tried it? Suddenly PSO is everywhere.

in Research/Science 1 year ago

Pumpkin seed oil is a weak natural DHT inhibitor and not effective for significant hair loss. Effective treatments include finasteride, minoxidil, and other medications.

community Scalp tension, massage therapy, and Botox! Let’s talk about it!

1 upvotes 1 month ago

The conversation discusses using adjunct therapies like scalp massage and Botox to enhance the effects of DHT inhibitors for hair loss. It also mentions using GHK-cu, finasteride, keto shampoo, and a natural topical DHT-reducing serum for hair regrowth and reduced shedding.

community 5-Months Update: Minoxidil + Red Light Therapy + Lifestyle Changes

1023 upvotes 1 year ago

The user reported positive hair regrowth after 5 months using Minoxidil, red light therapy, and lifestyle changes, including dietary improvements and stress reduction. They chose natural supplements like saw palmetto and beta-sitosterol over pharmaceutical DHT inhibitors like finasteride.

community Any experience on Natural DHT blocker?

6 upvotes 5 years ago

The conversation is about using natural DHT blockers like saw palmetto, pumpkin seed oil, and stinging nettle extract for hair loss. Saw palmetto is noted to potentially halt mild hair loss.

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Learn

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learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Rosemary

Is it better to use rosemary in shampoo or as a natural oil? Using rosemary as a natural oil is generally more effective than in shampoo.

learn Adenosine

Adenosine: How natural is this ingredient and how does it act on the scalp? Adenosine is a naturally occurring compound that promotes hair growth by extending the anagen phase.

learn Scalp Micropigmentation

Does scalp micropigmentation look natural? Scalp micropigmentation can look natural if performed by a skilled practitioner.

learn Hair Transplant

Do hair transplants look natural? When done correctly, hair transplants can look completely natural and undetectable.
Will eyebrow transplants look natural? Eyebrow transplants can look natural if performed by an experienced specialist.

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