The Anti-Muscle Atrophy Effects of Ishige Sinicola in LPS-Induced C2C12 Myotubes Through Antioxidant and Anti-Inflammatory Actions

The research investigated the effects of Ishige sinicola extract (ISE) and its butanol (BuOH) fraction on muscle atrophy in lipopolysaccharide (LPS)-induced C2C12 myotubes. The study found that ISE and its BuOH fraction significantly inhibited muscle atrophy by reducing the diameter of myotubes and downregulating the expression of muscle-specific E3 ubiquitin ligases (MAFbx and MuRF1). Additionally, they suppressed the LPS-induced expression of pro-inflammatory cytokines and inflammation-inducible enzymes. The study concluded that ISE and its BuOH fraction have potential as therapeutic agents for muscle atrophy due to their antioxidant and anti-inflammatory properties. Further studies are needed to investigate the bioactive compounds of the BuOH fraction from ISE with a potent muscle atrophy effect.