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This review critically assesses recent evidence (2020-2025) on the effectiveness of regenerative therapies like platelet-rich plasma, photobiomodulation, stem cells, and exosomes for treating androgenetic alopecia, highlighting the challenges physicians face due to commercialization and the evolving regulatory landscape.

Certain combination therapies, like microneedling with minoxidil, are more effective for female-pattern hair loss than other treatments.

This systematic review reports positive outcomes for platelet-rich plasma in aesthetic dermatology applications like skin rejuvenation, hair restoration, wound healing, and fat grafting, but highlights the need for standardized protocols in future research.

PRP injections can increase hair density in people with androgenic alopecia.

This study found that platelet-rich plasma therapy significantly increased hair diameter and density in male androgenetic alopecia patients over six months, particularly in those with AGA durations up to five years.

In this study, injections of PRP and MZT products significantly improved hair thickness, density, and count in AGA patients over six months, with variability observed in the extent of improvement between different formulations.

This qualitative study reported that platelet-rich plasma treatments improved patient satisfaction and quality of life by enhancing facial texture and hair quality, supporting PRP as a viable option for conditions like alopecia and skin rejuvenation.

In this split-scalp study, researchers observed that combining fractional CO2 laser and PRP treatment was significantly more effective in improving hair parameters in women with female pattern hair loss than using each intervention alone or placebo.

This review discusses the challenges in treating alopecia areata and the potential psychological impact, noting that spontaneous hair regrowth often occurs and highlighting the consideration of psychotherapy alongside treatment options; it reports no new experimental results.

This study found that platelet-rich plasma therapy may be a useful alternative to 5% topical minoxidil for treating androgenetic alopecia, with differences in the effectiveness and patient satisfaction outcomes observed.

This study found that platelet-rich plasma is effective and safe for treating chronic wounds, particularly diabetic and venous ulcers, and vitiligo, without increasing the risk of infection.

This study found that intralesional triamcinolone acetonide is more effective and faster than platelet-rich plasma in promoting hair regrowth for scalp alopecia areata.

This prospective randomized controlled trial found that combining platelet-rich plasma plus basic fibroblast growth factor injections with topical minoxidil significantly improves hair count and growth rate in androgenetic alopecia patients compared to either treatment alone.

This comprehensive review analyzes androgenetic alopecia treatments, discussing the mechanisms, costs, efficacy, and safety of FDA-approved drugs like minoxidil and finasteride, as well as newer non-FDA-approved options that have shown effectiveness across various studies.

This review discusses the potential of extracellular vesicles from various sources for skin rejuvenation and cosmetic use, noting promising results, especially with mesenchymal stem cell-derived vesicles, but reports no new clinical results.

This study suggests that cold atmospheric microwave plasma treatment may promote hair renewal by activating β-catenin and YAP/TAZ signaling in human dermal papilla cells.

This review suggests that microneedling shows promise for improving hair quality, thickness, and density in treating androgenetic alopecia, but standardized treatment protocols are currently lacking.

This study found that platelet-rich plasma injections significantly improved hair density in male patients with androgenetic alopecia compared to placebo treatments.

This study found that adding platelet-rich plasma to standard treatment reduced rebleeding in patients with peptic ulcer bleeding compared to additional epinephrine injections.

PRP may help with hair loss and improve hair quality with few side effects, but more research is needed.

Micrografts are useful for healing wounds, regenerating bone and periodontal tissues, and improving hair transplantation outcomes.

This article contains no research findings; it reports on an online discussion about platelet-rich plasma (PRP) and opinions shared during a conference.

This review concludes that platelet-rich plasma treatment is effective for androgenetic alopecia, with recommendations for a specific volume, frequency, and duration of therapy for optimal results.

This study compared the effectiveness and safety of microneedling with PRP versus minoxidil and finasteride topical therapy in adult males with androgenetic alopecia, finding similar hair density improvements in both groups, though microneedling with PRP had a quicker onset of action.

This review suggests that platelet-rich plasma may be a promising treatment for immune-mediated alopecias, including alopecia areata and primary cicatricial alopecias, but definitive recommendations are limited due to insufficient high-quality evidence.

This study found that intradermal administration of PRP combined with oral biotin significantly increased hair regrowth in men with androgenetic alopecia, without notable side effects.

This review discusses the potential of using SULT1A1 expression in the scalp as a biomarker to predict response to minoxidil treatment for androgenetic alopecia, but reports no new clinical results.

This study found that platelet-rich plasma injections improved alopecia severity scores in women with androgenetic alopecia after six months, though further research is needed to confirm these results.

In this study, a combination of GFM-lotion with autologous PRP treatment improved efficacy in treating androgenic alopecia compared to PRP alone, as shown by significant improvements in clinical assessments over 3 months.