Hair and Scalp

January 2019 in “ Springer eBooks ”

Margo Gkini, M Goisis, Sara Izzo

platelet-rich plasma androgenetic alopecia growth factors PDGF TGF VEGF IGF adipose-derived stem cells dermal nanofat system PRP AGA ADSCs

TLDR PRP may help with hair loss and improve hair quality with few side effects, but more research is needed.

The document from 2019 discusses the potential of platelet-rich plasma (PRP) as a treatment for androgenetic alopecia (AGA), highlighting its rich content of growth factors such as PDGF, TGF, VEGF, and IGF that can promote hair growth. It outlines the PRP treatment protocol, which includes multiple sessions and a booster, and reports improvements in hair loss, count, diameter, density, volume, and quality, with a low risk of adverse effects. However, it calls for more extensive trials to confirm PRP's efficacy and safety. The document also touches on the positive impact of adipose-derived stem cells (ADSCs) on hair growth and details a dermal nanofat system procedure for hair treatment, including the preparation and injection techniques. It suggests PRP could be used alone in early AGA stages or alongside conventional treatments in advanced cases, and it references studies on PRP, growth factors, and ADSCs in skin and hair treatments.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , March 2015 in “International Journal of Dermatology”

ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.

research Platelet-Rich Plasma as a Potential Treatment for Noncicatricial Alopecias

58 citations , January 2015 in “International Journal of Trichology”

Platelet-rich plasma, which carries growth factors, could be a promising treatment for non-scarring hair loss, promoting hair growth and density with no major side effects.

research Evaluation and Diagnosis of the Hair Loss Patient

69 citations , August 2014 in “Journal of The American Academy of Dermatology”

Trichoscopy is a quick, cost-effective tool for diagnosing different hair loss conditions.

research Evaluation and Diagnosis of the Hair Loss Patient

86 citations , August 2014 in “Journal of The American Academy of Dermatology”

To diagnose hair loss, use a systematic approach including history, exams, and tests.

research Platelet-Rich Plasma in Dermatology: Boon or Bane?

119 citations , January 2014 in “Indian Journal of Dermatology, Venereology and Leprology”

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations , October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations , December 2009 in “Journal of Dermatological Science”

Fat tissue stem cells may help increase hair growth.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , October 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles

136 citations , June 2006 in “Journal of Dermatological Science”

research Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

55 citations , September 2003 in “Experimental Dermatology”

PDGF signaling may play a role in hair growth cycle regulation.

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

33 citations , February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

IGF-1 increases whisker growth in transgenic mice.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

Related Research

5 / 5 results

research Advances in Hair Restoration: Wnt/Beta-Catenin Pathway and Stem Cell-Based Therapies

November 2021 in “Current Otorhinolaryngology Reports”

New treatments for hair loss could involve using stem cells and a process called the Wnt/beta-catenin pathway to stimulate hair growth.

research Platelet Lysate: A Promising Candidate in Regenerative Medicine

13 citations , January 2021 in “Regenerative Medicine”

Platelet lysate could be a valuable treatment for many diseases in regenerative medicine.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Novel Therapeutic Approaches in Utilizing Platelet Lysate in Regenerative Medicine: Are We Ready for Clinical Use?

51 citations , March 2019 in “Journal of cellular physiology”

Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.

research Autologous Platelet-Rich Plasma for the Treatment of Pattern Hair Loss

42 citations , May 2016 in “American Journal of Clinical Dermatology”

Using platelet-rich plasma, which is full of growth factors, can help treat pattern hair loss.

Hair and Scalp

Research cited in this study

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

research Platelet-Rich Plasma as a Potential Treatment for Noncicatricial Alopecias

research Evaluation and Diagnosis of the Hair Loss Patient

research Evaluation and Diagnosis of the Hair Loss Patient

research Platelet-Rich Plasma in Dermatology: Boon or Bane?

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

research PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles

research Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

Related Community Posts Join

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

community I have successfully stopped my hormone-induced hair loss ( caused by PCOS,) for 2 years now but I can't seem to be able to regrow the lost hair. Has anyone tried Platelet-Rich Plasma Therapy (PRP)?

community New and Interesting HairLoss Studies/Papers/Reviews

community Comparison of options: topical vs medication

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

community Hair Loss Factors in Moms: Analyzing Hormonal Changes, Stress, Genetics, and More

Related Research

research Advances in Hair Restoration: Wnt/Beta-Catenin Pathway and Stem Cell-Based Therapies

research Platelet Lysate: A Promising Candidate in Regenerative Medicine

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Novel Therapeutic Approaches in Utilizing Platelet Lysate in Regenerative Medicine: Are We Ready for Clinical Use?

research Autologous Platelet-Rich Plasma for the Treatment of Pattern Hair Loss