Hair and Scalp

January 2019 in “ Springer eBooks ”

Margo Gkini, M Goisis, Sara Izzo

platelet-rich plasma androgenetic alopecia growth factors PDGF TGF VEGF IGF adipose-derived stem cells dermal nanofat system PRP AGA ADSCs

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Vascular Endothelial Growth Factor →

Studysummary PRP may help with hair loss and improve hair quality with few side effects, but more research is needed. Our plain-language summary of this paper — not a Tressless recommendation.

The document from 2019 discusses the potential of platelet-rich plasma (PRP) as a treatment for androgenetic alopecia (AGA), highlighting its rich content of growth factors such as PDGF, TGF, VEGF, and IGF that can promote hair growth. It outlines the PRP treatment protocol, which includes multiple sessions and a booster, and reports improvements in hair loss, count, diameter, density, volume, and quality, with a low risk of adverse effects. However, it calls for more extensive trials to confirm PRP's efficacy and safety. The document also touches on the positive impact of adipose-derived stem cells (ADSCs) on hair growth and details a dermal nanofat system procedure for hair treatment, including the preparation and injection techniques. It suggests PRP could be used alone in early AGA stages or alongside conventional treatments in advanced cases, and it references studies on PRP, growth factors, and ADSCs in skin and hair treatments.

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Research cited in this study

15 / 15 results

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , March 2015 in “International Journal of Dermatology”

This retrospective study found that adipose-derived stem cell-conditioned media increased hair density and thickness in women with female pattern hair loss over 12 weeks, with no severe adverse effects reported.

research Platelet-Rich Plasma as a Potential Treatment for Noncicatricial Alopecias

58 citations , January 2015 in “International Journal of Trichology”

This review evaluates the therapeutic potential of platelet-rich plasma for treating non-cicatricial alopecias and suggests it may be effective, though further research is needed to confirm its efficacy.

research Evaluation and Diagnosis of the Hair Loss Patient

86 citations , August 2014 in “Journal of The American Academy of Dermatology”

This article discusses the history taking and clinical examination process for diagnosing alopecia and outlines a diagnostic approach, noting that it reports no new clinical results.

research Evaluation and Diagnosis of the Hair Loss Patient

69 citations , August 2014 in “Journal of The American Academy of Dermatology”

This review discusses recent advances in trichoscopy for differentiating types of alopecia and presents a systematic approach for using its diagnostic findings, but reports no new clinical results.

research Platelet-Rich Plasma in Dermatology: Boon or Bane?

119 citations , January 2014 in “Indian Journal of Dermatology, Venereology and Leprology”

This review discusses the use of platelet-rich plasma in various dermatological applications and reports no new clinical results; the authors call for more rigorous trials to confirm its effectiveness.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that PRP injections may improve hair density and reduce hair loss in patients with androgenetic alopecia without significant side effects, but further research is needed to confirm efficacy.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations , October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

This article discusses the development of an evidence-based guideline for treating androgenetic alopecia and reports no new research results.

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the paracrine effects of adipose tissue-derived stem cells on surrounding cells and tissues, noting their potential therapeutic benefits, but reports no new clinical results.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , October 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

In this study, platelet plasma growth factors from patients' autologous plasma improved follicular unit yield in baldness surgery by 15.1% compared to control areas.

research PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles

136 citations , June 2006 in “Journal of Dermatological Science”

This study found that injecting PDGF-AA and -BB into mouse skin immediately triggered the hair growth cycle's anagen phase, suggesting potential treatment options for certain types of alopecia.

research Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

55 citations , September 2003 in “Experimental Dermatology”

In this study, researchers found that certain cytokines can significantly down-regulate PDGF expression in dermal papilla cells and follicular keratinocytes, indicating a potential link between PDGF signaling and catagen induction.

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

33 citations , February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that overexpression of IGF-1 in transgenic mice stimulated increased vibrissa growth during the first neonatal hair cycle compared to their nontransgenic littermates.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations , November 1996 in “Molecular Medicine Today”

This review discusses the role of growth factors and cytokines in hair follicle development and cycling, but reports no new clinical findings on treatments for hair growth disorders.

research Soluble Factors From Human Hair Papilla Cells And Dermal Fibroblasts Dramatically Increase The Clonal Growth Of Outer Root Sheath Cells

62 citations , June 1993 in “Archives of Dermatological Research”