January 2023 in “Han'gug mi'saengmul saengmyeong gong haghoeji/Han-guk misaengmul saengmyeong gonghak hoeji” This study found that a mixed extract of N. jatamansi, O. basilicum, and C. sativus, particularly when extracted via steaming and ultrasonic methods, increased antioxidant content, stimulated melanin production for black hair, and promoted hair growth in mouse models, while maintaining high cell viability.
1 citations
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October 2021 in “Clinical, Cosmetic and Investigational Dermatology” In this study on cultured human dermal papilla cells, researchers found that niacinamide may enhance hair growth by reducing oxidative stress-induced cell senescence and delaying catagen entry, suggesting potential applications against hair loss.
January 2016 in “Jurnal Farmasi Indonesia” In this study, hibiscus leaf extract hair tonic at 10% concentration showed better hair growth promotion activity compared to minoxidil 2% in a rabbit model, although it caused eye irritation.
57 citations
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March 2022 in “Biomedicine & Pharmacotherapy” This study found that methanol extract from Anisomeles indica has significant antidepressant and antidiarrheal effects in animal models and notable anti-inflammatory activity in vitro.
February 2023 in “Molecules” In this study, N. ottonis cactus cell extract applied to mice promoted hair growth and increased the number of hair follicles, suggesting its potential as a hair-growth-promoting agent.
January 2024 in “Journal of Medicinal Food” This study found that Nephelium lappaceum extract restored hair growth more effectively than finasteride in mice with testosterone-inhibited hair growth, suggesting its potential as a nutraceutical for hair growth.
January 2026 in “Journal of Ethnopharmacology” This study found that naringin, a natural flavonoid, significantly improved hair growth in mice by activating the Wnt/β-catenin pathway, with the 4% concentration showing comparable efficacy to 5% minoxidil, suggesting naringin as a promising alternative for alopecia treatment.
1 citations
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October 2018 in “International research journal of pharmacy” This study found that ethanol extract and n-hexane fraction of rampai leaves may stimulate hair growth in rabbits, showing potential as an anti-alopecia treatment.
30 citations
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January 2016 in “BioMed Research International” This study identified corilagin as a major antitumor component in Phyllanthus niruri, with broad-spectrum activity against cancer cells and high content in Dimocarpus longan.
January 2025 in “International Journal of Pharmacognosy and Pharmaceutical Research” This study found that hydroalcoholic extracts of Bacopa monnieri demonstrated significant antimitotic activity in an Allium cepa model, suggesting potential comparable effects to the standard drug methotrexate.
1 citations
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June 2023 in “International Journal of Scientific Research in Science and Technology” The researchers highlighted the nutritional benefits of kiwifruit, noting its high vitamin C content, dietary fiber, and potassium, as well as its wealth of phytochemicals and antioxidants, which may aid immune function, digestion, and potentially reduce chronic disease risk.
This study evaluated formulations of a nanoemulsion with mangkokan leaves extract and candlenut oil, predicting its effectiveness for enhancing hair growth in male Sprague Dawley rats, with nanoemulsions showing assumed stable physical characteristics after two weeks.
This study found that bitter melon leaf extract, particularly at a 10% concentration, promoted hair growth in male rabbits, outperforming the effect of a 2% minoxidil solution.
1 citations
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June 2021 in “Journal of Korean Medicine for Obesity Research” Corni Fructus extract may help manage benign prostatic hyperplasia by reducing prostate cell growth and inflammation.
13 citations
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December 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that nicotinamide can effectively inhibit human hair growth and promote hair follicle regression in cultured human scalp models without negatively affecting epidermal vitality, suggesting its potential as a hair growth inhibitor in cosmetic applications.
2 citations
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July 2025 in “Acta Pharmacologica Sinica” Isoginkgetin reduces inflammation in cells by blocking NF-κB activation.
October 2025 in “Asian Journal of Pharmaceutical Research and Development” This study reported that phytosome formulations of citrus flavonoids naringenin and naringin showed significantly increased oral bioavailability and plasma drug concentration in rabbits, suggesting that phytosome technology effectively addresses the pharmacokinetic limitations of these compounds.
14 citations
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February 2021 in “International Journal of Pharmaceutics” In this study, applying deer antler velvet extract-loaded niosomes and microspicules serum to the scalp significantly improved hair growth, melanin content, and skin hydration over 14 to 30 days without causing skin irritation.
September 2023 in “Jurnal MIPA (edisi elektronik)” This study formulated and evaluated the physical stability of hair tonic preparations using lime extract (Citrus aurantifolia) at varying concentrations. The researchers found that the tonics exhibited good physical stability, as indicated by meeting Indonesian National Standards, even after undergoing temperature cycling tests.
July 2022 in “Forte Journal” In this study, researchers tested hair tonic formulations with varying concentrations of bitter melon extract and found that higher concentrations enhanced hair growth in rabbits, with the 15% extract showing the greatest effect without causing skin irritation.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This research highlights that Amalaki demonstrates cardiometabolic and hepatic benefits in human trials, while narrative synthesis of preclinical studies suggests promise in hair, skin, ocular, cognitive, and respiratory health.
1 citations
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February 2022 in “International Journal of Health and Pharmaceutical (IJHP)” This study found that a combination of cantigi and henna leaf extracts, in a 1:2 ratio, demonstrated the strongest antioxidant activity with an IC50 value of 29.85 µg/mL.
March 2018 in “International Pharmacy Acta” This study concluded that niosomes could effectively serve as stable carriers for topical aminexil delivery, showing promising stability and a slow, biphasic release profile in laboratory settings.
July 2024 in “Natural Product Research” Nk-EE may help treat hair loss by promoting hair growth and preventing hair follicle damage.
27 citations
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December 2005 in “Journal of Cosmetic Dermatology” This study found that topical application of niacin derivatives significantly increased hair fullness in women with female pattern hair loss compared to a placebo after six months.
May 2024 in “Jurnal Penelitian Farmasi dan Herbal” In this experimental study using male rabbits, researchers found that a 7.5% concentration of green tea leaf ethanol extract hair tonic was nearly as effective in promoting hair growth as the positive control, minoxidil, over a 21-day period.
January 2026 in “Romanian Journal of Military Medicine” This study found that both Lactobacillus casei extract and Newcastle disease virus significantly reduced cell viability and induced apoptosis in human colorectal cancer cells, suggesting these agents could complement standard chemotherapy and radiotherapy after further clinical trials.
6 citations
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May 2023 in “European journal of pharmaceutical sciences” This study found that niosomes significantly enhanced the skin deposition of retinoic acid while reducing its permeation, outperforming other tested nanoformulations.
2 citations
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November 2021 in “International Journal of Applied Pharmaceutics” This study found that a phytosome lotion made from Mangkokan leaf extract, using a green solvent and microwave-assisted extraction, demonstrated greater hair growth activity than 2% minoxidil, with the 30% phytosome lotion showing the highest efficacy in increasing hair length, weight, and diameter.
2 citations
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March 2021 in “Journal of nanoscience and nanotechnology” This study suggests that nanoliposomes encapsulating saw palmetto CO2 extract could be effective for delivering drugs to treat hair loss due to their small size, dispersion, and negative charge.