Naringin Promotes Hair Regeneration Via Wnt/β-Catenin Pathway: A Dose-Dependent Study In C57BL/6J Mice

This study investigates the effects of naringin, a flavonoid found in citrus fruits, on hair regeneration in C57BL/6J mice, focusing on its interaction with the Wnt/β-catenin signaling pathway. The research demonstrates that a 4% concentration of naringin significantly promotes hair growth, surpassing the efficacy of 5% minoxidil, a common hair loss treatment. Naringin enhances hair follicle density and cell proliferation by upregulating key proteins such as β-catenin, Wnt10b, and VEGF-A, while reducing Wnt5a. Molecular docking analysis confirms stable binding between naringin and β-catenin, suggesting a specific interaction that mediates its effects. This study supports the potential of naringin as a promising alternative for alopecia treatment, validating traditional Chinese medicine with modern scientific methods.