Naringin Promotes Hair Regeneration Via Wnt/β-Catenin Pathway: A Dose-Dependent Study In C57BL/6J Mice

    January 2026 in “ Journal of Ethnopharmacology ”
    XianPing Zheng, JingLu Hu, Zhiqiang Chen … Bojie Lin
    Studysummary This study found that naringin, a natural flavonoid, significantly improved hair growth in mice by activating the Wnt/β-catenin pathway, with the 4% concentration showing comparable efficacy to 5% minoxidil, suggesting naringin as a promising alternative for alopecia treatment.
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    Research cited in this study 22

    1. Effect of Topical Naringenin and Its Combination With Minoxidil on Enhancing Hair Growth in a Mouse Model PubMed · 2023
    2. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    3. Novel 'After Minoxidil' Spray Improves Topical Minoxidil Compliance and Hair Style Manageability Journal of Cosmetic Dermatology · 2020
    4. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    5. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    6. A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss Clinical and Experimental Dermatology · 2018
    7. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    8. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    9. Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study Indian Journal of Dermatology, Venereology and Leprology · 2016
    10. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    11. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    12. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    13. L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase British journal of dermatology/British journal of dermatology, Supplement · 2009
    14. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    15. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    16. Male Pattern Androgenetic Alopecia Skinmed · 2006
    17. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    18. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    19. Treatment of Hair Loss The New England Journal of Medicine · 1999
    20. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    21. Androgens and Human Hair Growth Clinical endocrinology · 1994
    22. The Secret Life of the Hair Follicle Trends in genetics · 1992