Effect of Topical Naringenin and Its Combination With Minoxidil on Enhancing Hair Growth in a Mouse Model

The study investigated the efficacy of naringenin (NAR), a compound with antioxidant and anti-inflammatory properties, in reducing hair loss. The experiment involved 24 adult Wistar Albino mice, divided into four groups of six. The groups were treated with ethanol alcohol, minoxidil (5%), 0.5% naringenin, and a combination of naringenin and minoxidil. The treatment groups showed significantly higher total antioxidant capacity in tissue levels and increased serum levels of vascular endothelial growth factor compared to the control group. There were no significant differences in keratinocyte growth factor tissue levels between the treatment and control groups. However, the medication significantly increased hair growth, hair follicle diameter expansion, and hair follicle quantity compared to the control group. The results suggest that NAR significantly reduced hair loss in adult male mice.