Bioguided Fraction and Isolation of the Antitumor Components from Phyllanthus Niruri L.

    January 2016 in “ BioMed Research International ”
    Zhizhong Zheng, Lianghua Chen, Shao-Song Liu, Yuan Deng, Guohua Zheng, Yue Gu, Yanlin Ming
    Studysummary This study identified corilagin as a major antitumor component in Phyllanthus niruri, with broad-spectrum activity against cancer cells and high content in Dimocarpus longan.
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    The study investigated the antitumor properties of Phyllanthus niruri L., focusing on its effects on hepatocellular carcinoma (HCC) cells. Researchers identified corilagin as the primary antitumor component, which significantly inhibited HCC cell growth with low toxicity to normal cells. Corilagin demonstrated broad-spectrum antitumor activity and was found in high concentrations in Dimocarpus longan Lour. The study concluded that corilagin is the major active antitumor compound in P. niruri L., offering potential for cancer treatment, although further research on its mechanisms was needed.
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