Bioguided Fraction and Isolation of the Antitumor Components from Phyllanthus Niruri L.

The study investigated the antitumor components of Phyllanthus niruri L., identifying ethyl brevifolincarboxylate and corilagin as key compounds through various chromatographic and spectrometric methods. Corilagin demonstrated broad-spectrum antitumor activity with low toxicity to normal cells and enhanced the antitumor effect of cDDP, as indicated by a coefficient of drug interaction of 0.77. Among 10 plant species analyzed, Dimocarpus longan Lour. was found to have the highest corilagin content. The research concluded that corilagin is the primary active antitumor component in P. niruri, particularly effective against HCC cells.