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30-60 / 1000+ resultsresearch Epigenetics of Colorectal Cancer
This review discusses the role of epigenetics in colorectal cancer and explains how changes like DNA methylation impact tumor development, but it reports no new results.
research Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
This paper reviews the emerging potential of menstrual blood-derived mesenchymal stem cell extracellular vesicles in regenerative medicine, highlighting their promise for treating several diseases without providing new clinical results.
research Engineered extracellular vesicles for tissue repair and regeneration
This review summarizes the therapeutic potential and development of engineered extracellular vesicles for tissue repair and regenerative medicine, reporting no new clinical findings.
research Long and short non-coding RNA and radiation response: a review
This review discusses the role of noncoding RNAs (ncRNAs) in radiation response and highlights their potential as biomarkers for assessing radiation damage, but reports no new clinical results.
research MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy
This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.
research Extracellular Vesicles for Regenerative Medicine Applications
This review discusses the potential of extracellular vesicles as cell-free tools in tissue engineering and regenerative medicine, noting their emerging role in promoting tissue repair without the risk of host rejection.
research Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
This review discusses the potential of miRNA-mediated hair growth treatments for androgenetic alopecia by targeting DKK1 to modulate the Wnt/β-catenin signaling pathway and reports no new clinical findings.
research The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives
This review summarizes the role of non-coding RNAs in hair follicle regeneration and highlights potential therapeutic strategies, though it reports no new experimental results.
research Extracellular vesicles in age-related diseases: disease pathogenesis, intervention, and biomarker
This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.
research Regenerative Medicine
This review discusses the potential of regenerative medicine for chronic and neuro-degenerative pain conditions and reports no new clinical results; the authors note that further trials are needed to confirm its efficacy.
research Exosomes in stroke management: A promising paradigm shift in stroke therapy
This research review highlights the potential of exosome therapy to transform stroke treatment, reporting that in animal models, exosomes can reduce neuroinflammation, oxidative stress, and cell death, while promoting brain repair and regeneration. However, more evidence is needed before clinical applications in humans are established.
research Fabrication of carboxymethyl cellulose/hyaluronic acid/polyvinylpyrrolidone composite pastes incorporation of minoxidil-loaded ferulic acid-derived lignin nanoparticles and valproic acid for treatment of androgenetic alopecia
In this study, researchers developed a composite paste system using minoxidil-loaded nanoparticles and valproic acid, enhanced by roller-microneedles, which significantly stimulated hair regeneration and perifollicular vascularization in an androgenetic alopecia mouse model, reducing side effects compared to traditional treatments.
research Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways
In this study, researchers identified key transcriptome changes in male androgenetic alopecia hair follicles, suggesting that HIF-1 pathway genes and Wnt pathway inhibitors could be potential therapeutic targets.
research Hair Follicles as Micro-Organs: MicroRNA-Mediated Control of Growth, Cycling, and Fiber Traits
This review highlights the critical role of microRNAs in regulating hair follicle biology, significantly impacting wool and cashmere development by modulating gene expression and signaling pathways in sheep and goats.
research Clinical Applications of Extracellular Vesicles: Promises and Pitfalls
This review explores the potential roles of extracellular vesicles in various medical fields, emphasizing their promise but noting the need for standardization and clinical testing before widespread application.
research Exosome-based Therapies for Androgenetic Alopecia: Mechanisms, MicroRNAs, and Clinical Prospects
This review explores the potential of exosomes, which contain substances that may stimulate hair follicle activity, as a new therapeutic strategy for alopecia, and discusses their possible benefits and risks based on current knowledge of microRNAs and intracellular signaling in hair follicle morphogenesis.
research Exploring lncRNA-Mediated Mechanisms in Muscle Regulation and Their Implications for Duchenne Muscular Dystrophy
This review compiles current research on the role of long non-coding RNAs in regulating muscle growth and regeneration processes, particularly their influence on Duchenne muscular dystrophy, and reports no new clinical results.
research Alteration of hair growth in mice by circulating exosomes from Xinji fine-wool and small-tailed Han sheep
In this study, researchers found that circulating exosomes from different sheep breeds can significantly alter hair growth in mice, with the source of exosomes influencing hair follicle size and hair diameter, as well as expression of specific hair growth and melanin synthesis markers.
research Molecular Morbidity Score–Can MicroRNAs Assess the Burden of Disease?
This article proposes using the hallmarks of ageing and dysregulated microRNAs to create a molecular morbidity score that could improve prognostication and clinical trial inclusion for patients with multimorbidity.
research Research Progress on Targeted Regulation of Hair Follicle Stem Cell Function in the Treatment of Androgenetic Alopecia
New treatments using stem cells and other methods show promise for promoting hair growth in androgenetic alopecia.
research Harnessing mesenchymal aggregation for engineered organ‐level regeneration: Recent progress and perspective
In this review, it is discussed how mesenchymal stem cell aggregation plays a crucial role in organ development and has potential applications in organ regeneration through tissue engineering.
research Regulation of somatic cell reprogramming through inducible mir-302 expression
This study found that induced expression of mir-302 can reprogram human hair follicle cells into induced pluripotent stem cells through a novel epigenetic mechanism involving global demethylation.
research miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes
This study found that increasing the levels of specific microRNAs from the miR-17∼92 cluster improved wound healing in mice by reducing inflammation, suggesting a potential therapeutic approach for chronic wounds.
research Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling
Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
research miR‐218‐5p regulates skin and hair follicle development through Wnt/β‐catenin signaling pathway by targeting SFRP2
In this study, miR-218-5p was found to enhance hair shaft growth and positively regulate the Wnt signaling pathway by targeting SFRP2 during skin and hair follicle development.
research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes
In this study, researchers observed that hyperandrogenic PCOS patients exhibited distinct miRNA and TGFβ signaling gene expression patterns in granulosa cells, suggesting these factors may play a role in PCOS pathogenesis.
research Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22
This study found that the microRNA miR-22 is a key regulator of the hair cycle, influencing hair loss by promoting the transition from growth to rest phases and repressing keratinocyte differentiation.
research Transcriptional Characteristics Showed That miR-144-y/FOXO3 Participates in Embryonic Skin and Feather Follicle Development in Zhedong White Goose
This study identified key genes and miRNAs involved in feather morphogenesis in Zhedong White geese, highlighting a negative correlation between FOXO3 and miR-144-y.
research miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma
This study reports that miR-22 promotes cancer progression and metastasis by maintaining Wnt/β-catenin signaling and cancer stem cell function.