MiR-29 Is an Important Driver of Aging-Related Phenotypes

    December 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Vijay Swahari, Ayumi Nakamura, Émilie Hollville, Yu‐Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, Shirley He, Janakiraman Krishnamurthy, Sahil Kapoor, V. S. Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman E. Sharpless, Carlos López-Otı́n, Praveen Sethupathy, Mohanish Deshmukh
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    TLDR miR-29 is a key factor that accelerates aging.
    The study investigates the role of microRNA miR-29 in aging by using mouse and monkey models to confirm its upregulation during normal and premature aging. The researchers found that miR-29 is a top microRNA driving aging-related gene expression changes. They demonstrated that reducing miR-29 levels extends lifespan in Zmpste24 -/- mice, a model of accelerated aging. Additionally, they created mice with conditional overexpression of miR-29 (miR-29TG) and observed that its overexpression induces aging-related phenotypes such as alopecia, kyphosis, osteoporosis, senescence, and early lethality. Transcriptomic analysis showed that both young miR-29TG and old wild-type mice had similar gene expression changes, with downregulation in extracellular matrix and fatty acid metabolism genes, and upregulation in inflammation-related genes, underscoring miR-29's significant role in aging.
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