MiR-29 Is an Important Driver of Aging-Related Phenotypes

    December 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Vijay Swahari, Ayumi Nakamura, Émilie Hollville, Yu‐Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, Shirley He, Janakiraman Krishnamurthy, Sahil Kapoor, V. S. Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman E. Sharpless, Carlos López-Otı́n, Praveen Sethupathy, Mohanish Deshmukh
    Image of study
    TLDR miR-29 is a key factor that accelerates aging.
    The study investigates the role of microRNA miR-29 in aging by using mouse and monkey models to confirm its upregulation during normal and premature aging. The researchers found that miR-29 is a top microRNA driving aging-related gene expression changes. They demonstrated that reducing miR-29 levels extends lifespan in Zmpste24 -/- mice, a model of accelerated aging. Additionally, they created mice with conditional overexpression of miR-29 (miR-29TG) and observed that its overexpression induces aging-related phenotypes such as alopecia, kyphosis, osteoporosis, senescence, and early lethality. Transcriptomic analysis showed that both young miR-29TG and old wild-type mice had similar gene expression changes, with downregulation in extracellular matrix and fatty acid metabolism genes, and upregulation in inflammation-related genes, underscoring miR-29's significant role in aging.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 23 results

      community Getting dutasteride in germany

      in Finasteride/Dutasteride  18 upvotes 4 months ago
      You can get dutasteride in Germany through the Teleclinic app, which sends a prescription to a nearby pharmacy. It costs around 18-19 euros for the prescription and 47 euros for 90 pills of Avodart 0.5.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Megadosing Koshine826(Pyrilutamide), my Plan.

      in Treatment  1 upvotes 2 months ago
      The user plans to use 1% Koshine826, 0.1% Alfatradiol, Minoxidil with Tretinoin, microneedling, and Stemoxydine for hair loss treatment. They expect significant recovery with this regimen.

      community Help in Germany to get recommended medicine

      in Finasteride/Dutasteride  5 upvotes 3 months ago
      A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

    Similar Research

    5 / 1000+ results